Banca de QUALIFICAÇÃO: JOANNA DE ANGELIS DA COSTA BARROS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: JOANNA DE ANGELIS DA COSTA BARROS
DATA: 16/02/2012
HORA: 09:00
LOCAL: Sala de Aula do PPGCSA, 2º andar do CCS - UFRN
TÍTULO:

ASSESSMENT OF ANTIOXIDANT AND ANTIPROLIFERATIVE ACTIVITY OF TROPICAL FRUIT AQUEOUS EXTRACT

PALAVRAS-CHAVES:

antioxidant; antiproliferative; tropical fruits; functional foods

PÁGINAS: 23
GRANDE ÁREA: Ciências Biológicas
ÁREA: Bioquímica
RESUMO:

The antioxidant activity of aqueous extracts of five edible tropical fruits (Spondias lutea, Hancornia speciosa, Spondias purpurea, Manilkara zapota and Averrhoa carambola) was investigated using different methods. The amount of phenolic compounds was determined by the Folin-Ciocalteu reagent. Extracts showed neither reducing power nor iron chelation (between 0.01 and 2.0 mg/mL). H. speciosa exhibited the highest superoxide scavenging activity (80%, 0.5 mg/mL). However, at high concentrations (8.0 mg/mL) only A. carambola, S. purpurea and S. lutea scavenging 100% of radicals formed. M. zapota and S. purpurea had higher phenolic compound levels and greater OH radical scavenging activity (92 %, 2 mg/mL). Antiproliferative activity was assessed with 3T3 fibroblasts and cervical tumor cells (HeLa). The most potent extract was S. purpurea (0.5 mg/mL), which inhibited Hela cell proliferation by 52%. All fruits showed antioxidant and antiproliferative properties, characterizing them as functional foods.

MEMBROS DA BANCA:
Interno - 347652 - CLODOMIRO ALVES JUNIOR
Presidente - 2195251 - HUGO ALEXANDRE DE OLIVEIRA ROCHA
Interno - 350753 - VALERIA SORAYA DE FARIAS SALES