Banca de DEFESA: ANDRÉA SILVA DE MEDEIROS BANDEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANDRÉA SILVA DE MEDEIROS BANDEIRA
DATE: 23/04/2025
TIME: 09:00
LOCAL: Google Meet
TITLE:

Organization and Morphology of the Raphe Nuclei in Chicken Embryos (Gallus gallus domesticus)

KEY WORDS:

Raphe nuclei, Serotonin (5HT), Neurodevelopment, Chicken embryo, Neuronal morphology

PAGES: 64
BIG AREA: Ciências Biológicas
AREA: Morfologia
SUBÁREA: Anatomia
SPECIALTY: Anatomia Animal
SUMMARY:

The raphe nuclei, located along the midline of the brainstem, are primarily composed of serotonergic neurons, which play essential roles in modulating physiological and behavioral functions. Although extensively studied in mammals, there is a significant gap in knowledge regarding the organization and morphology of these nuclei in birds, especially during embryonic development. This study aimed to morphologically characterize the raphe nuclei in 19-day-old chicken embryos (Gallus gallus domesticus), describing their structural organization and the morphology of serotonin-immunoreactive (5HT) cells.

Ten embryos were used, incubated under controlled conditions. The brains were extracted, processed by microtomy, and subjected to Nissl staining and immunohistochemistry for 5HT. Morphological analysis revealed the rostrocaudal organization of the raphe nuclei, including the rostral linear nucleus, dorsal raphe nucleus, and magnus raphe nucleus, among others. Serotonin-immunoreactive neurons were predominantly rounded and distributed in specific patterns along the brainstem.

The results indicate that the organization of the raphe nuclei in chicken embryos presents phylogenetic similarities with other vertebrate classes, reinforcing their importance in regulating neuromodulatory processes from early developmental stages. The delineation of these nuclei contributes to understanding the role of serotonin in neural maturation and its potential implications for neuropsychiatric disorders. These findings provide valuable insights for future research in comparative neuroscience and the development of experimental models for studying serotonin-related disorders.

COMMITTEE MEMBERS:
Presidente - 4363493 - EXPEDITO SILVA DO NASCIMENTO JUNIOR
Externo ao Programa - 1217155 - GUSTAVO DA CUNHA LIMA FREIRE - UFRNExterna à Instituição - ISABELI LINS PINHEIRO - UFPE