Banca de QUALIFICAÇÃO: LUDMILA THAINA CHAVES FREITAS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : LUDMILA THAINA CHAVES FREITAS
DATE: 25/02/2025
TIME: 14:00
LOCAL: REMOTO
TITLE:

THE EFFECTS OF CREATINE MONOHYDRATE SUPPLEMENTATION ON THE HISTOLOGICAL EVALUATION OF THE TESTIS AND LIVER OF DIABETIC RATS

KEY WORDS:

diabetes; creatin; histopathology.

PAGES: 26
BIG AREA: Ciências Biológicas
AREA: Morfologia
SUBÁREA: Histologia
SUMMARY:

Diabetes Mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia, which causes disturbances in insulin secretion and/or action and is associated with long-term damage and dysfunction of various tissues and organs, such as the liver and testes. Diabetes induces oxidative stress in the liver, characterized by an increase in the concentration of reactive oxygen species (ROS) in tissues and a significant reduction in antioxidant defenses. This imbalance may play a significant role in the development of chronic diabetic liver disease, including non-alcoholic fatty liver disease and its potential progression to steatohepatitis and cirrhosis.

Although the exact mechanism by which DM affects fertility remains unknown, among the various hypothetical mechanisms behind reproductive dysfunction, increased cellular oxidative stress due to excessive ROS production and decreased antioxidant capacity play a fundamental role in reproduction. In addition to inflammatory responses, testicular oxidative stress induced by hyperglycemia can also trigger programmed cell death, known as apoptosis, which is the main pathogenic mechanism of tissue injury and organ dysfunction. The accumulation of ROS in DM activates the apoptotic signaling pathway in the testes through the upregulation of pro-apoptotic proteins, such as Bax proteins and caspases like caspase-9.

Currently, many scientific studies aim to evaluate ways to improve the quality of life of diabetic patients and reduce the metabolic effects of DM. Over the past two decades, the role of nutritional supplements has been increasingly highlighted by the scientific community and regularly discussed in society. Among these, those involved in glycemic control—particularly creatine, alpha-methylguanidino-acetic acid—have emerged as a promising substance in adjunctive diabetes therapy and have thus been increasingly studied in recent years.

Considering the mechanisms underlying DM and the understanding of the effects and uses of creatine as a natural supplement in various clinical conditions, as well as its metabolic relationship with the liver and energy-related function in the testes, this study is pioneering in investigating the effects of creatine supplementation through the morphological evaluation of the liver and testes of diabetic rats induced by streptozotocin.

COMMITTEE MEMBERS:
Interno - 1667882 - BENTO JOAO DA GRACA AZEVEDO ABREU
Interna - 3357609 - FABIANE FERREIRA MARTINS
Interna - 2477216 - NAISANDRA BEZERRA DA SILVA FARIAS