Banca de QUALIFICAÇÃO: ANA LÚCIA MIRANDA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ANA LÚCIA MIRANDA
DATE: 22/08/2024
TIME: 10:00
LOCAL: REMOTA - https://meet.google.com/txz-umac-cbg
TITLE:

Body composition from CT and 3-year survival in colorectal cancer: A multicenter cohort.

KEY WORDS:

Body Composition; Muscle Tissue; Nutrition Assessment; Colorectal Cancer; Survival Analyses

PAGES: 28
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Background: Population-specific cut points are essential for accurately interpreting body composition assessments, especially in catabolic diagnoses like colorectal cancer (CRC). Current proposed cut points are validated for European, North American, or Asian populations.

Objective: this study aimed to: i) evaluate the distribution of body composition derived from computed tomography (CT) scans in Brazilian patients with CRC; and ii) assess the associations of this distribution with overall survival.

Methods: This multicenter cohort study was conducted in six Oncology units in Brazil, including patients (>18 years) diagnosed with CRC, without prior treatment. CT-based body composition (cm²) was assessed using Slice O’ Matic® and included: skeletal muscle cross-sectional area (both total and normalized to height², SM and SMI), skeletal muscle radiodensity (SMD in HU), intermuscular adipose tissue (IMAT), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT). Survival analyses were performed at 12, 24, and 36 months.

Results: A total of 635 patients were included (50.2% females, 56.5% older adults). Stages III to IV were the most frequent (57.5%), with similar tumor site distribution (rectum 51%). Based on tertile distributions, body composition was classified as: Low i) SMD < 32.4 for males (M), < 26.7 for females (F); ii) SM < 133.8 M, < 91.3 F; iii) SMI < 48.3 M, < 38.6 F. High: i) SAT > 122.3 M, > 200.2 F; ii) VAT > 168.6 M, > 114.4 F; iii) IMAT > 10.3 M, > 11.5 F. Low SMD, SM and SMI were independently associated with higher mortality hazard at all time points.

Conclusions: The distribution of body composition in our study differed notably from those described in other populations, underscoring the importance of population-specific cut points. Using our classification, low muscle health (by SM, SMI, and SMD) was independently associated with overall survival.

COMMITTEE MEMBERS:
Presidente - 1879430 - ANA PAULA TRUSSARDI FAYH
Externa à Instituição - FLÁVIA MORAES SILVA - UFCSPA
Externo à Instituição - NILIAN CARLA SILVA SOUZA