Banca de DEFESA: ONY ARAÚJO GALDINO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ONY ARAÚJO GALDINO
DATE: 28/07/2023
TIME: 09:00
LOCAL: DEFESA REMOTA - meet.google.com/cyf-vvjw-msm
TITLE:

THE NEPHROPROTECTIVE ACTION OF PASSIFLORA EDULIS IN STREPTOZOTOCIN-INDUCED DIABETES

KEY WORDS:

Adjuvant therapy; diabetic kidney disease; Passiflora edulis; Kidney injury; Diabetes.

PAGES: 27
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

In the present study, we aimed to evaluate the therapeutic effect of Passiflora edulis fruit peel aqueous (AFA) extract as an adjuvant to insulin to confer nephroprotection against streptozotocin-induced diabetes. Male Wistar rats were divided into four groups based on treatment received for 60 days: diabetic (DB), control (CTL), insulin (INS), and insulin + AFA extract (INS+AFA). mRNA and protein expression levels of podocyte (nephrin, podocin, and WT1) and tubular (megalin) proteins were measured in kidney tissue specimens and urine. Biochemical parameters and kidney histopathology were also examined. Herein, the INS+AFA group showed superior glycemic control, which resulted in the reduction of urinary albumin/creatinine ratio, maintenance of baseline levels of Nphs1, Nphs2, Wt1, and Lrp2 mRNA expression, prevention of protein loss from the kidney tissue into the urinary space, along with the maintenance of glomerular basement membrane thickness, hyalinization, glomerular and tubulointerstitial fibrosis at values approximating those of the CTL group and significantly lower than those in the DB group. Therefore, these results suggest that, as an anti-diabetic agent, the AFA extract adjuvant to insulin could reduce and potentially prevent diabetic kidney disease.

COMMITTEE MEMBERS:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externa ao Programa - 1663052 - IVANISE MARINA MORETTI REBECCHI - nullExterno à Instituição - JEFFERSON ROMÁRYO DUARTE DA LUZ - UEAP