Banca de DEFESA: GALTIERI OTAVIO CUNHA DE MEDEIROS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : GALTIERI OTAVIO CUNHA DE MEDEIROS
DATE: 18/04/2022
TIME: 14:30
LOCAL: DEFESA REMOTA - https://meet.google.com/nir-mtpb-zqk
TITLE:

MUSCLE CHARACTERISTICS ASSESSMENT BY COMPUTED TOMOGRAPHY IMAGE: COMPARISON BETWEEN ANATOMICAL LANDMARKS.

KEY WORDS:

low muscle mass,sarcopenia, body composition, muscle quality, muscle radiodensity, muscle attenuation.

PAGES: 25
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Studies evaluating low muscle mass (or sarcopenia) by computed tomography (CT) images often evaluate the third lumbar vertebrae (L3). However, lower limbs appendicular muscles are more involved in balance, physical function, locomotion, and daily activities. This study aimed to compare the assessment of skeletal muscle area (SMA in cm²), skeletal muscle index (SMI in cm²/m²) and skeletal muscle density (SMD in HU) between third lumbar vertebra (L₃) and thigh landmarks, and the agreement in diagnosing low muscle mass and low SMD (L₃ as the reference method). This was multicenter cross-sectional study including healthy individuals (≥ 18 years old) of both sexes, who had an elective CT exam including abdominal and pelvic regions. CT images were analyzed to evaluate SMA, SMI and SMD. Muscle abnormalities (low SMA, SMI, and SMD) were defined as values below the 5th percentile from a subsample of healthy young individuals (n=111; 18-39 years; 55,9% female). Correlation coefficients, Bland-Altman graphs and receiver operating characteristic (ROC) curves were calculated for the total sample and stratified by sex and age. A total of 268 individuals (44.3 ± 15.2 years) were evaluated (53% female). Significant (p <0.001 for all analysis) and strong correlations between SMA (rho = 0.896), SMI (rho = 0.853), and SMD (rho = 0.864) compared to L₃ and thigh landmarks were observed. For the ROC curves, similar AUC values were obtained for males (0.981), females (0.895), younger (0.902) and older adults (0.894). Muscle characteristics between L₃ and thigh landmarks have a strong correlation. This suggests that images of the thigh can be used to characterize muscle characteristics. Image acquisition and analysis of thigh region is simpler, with less radiation exposure, and consequently more appropriate for longitudinal analysis.

BANKING MEMBERS:
Externo à Instituição - FRANCISCO ABAETE DAS CHAGAS NETO
Presidente - 1879430 - ANA PAULA TRUSSARDI FAYH
Externo à Instituição - JOSE BARRETO CAMPELLO CARVALHEIRA - UNICAMP