Banca de DEFESA: DANIEL TORRES PEREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : DANIEL TORRES PEREIRA
DATE: 13/04/2022
TIME: 14:30
LOCAL: DEFESA REMOTA - https://meet.google.com/tzk-baqh-pgi
TITLE:

QUALITY BY DESIGN (QBD) BASED APPROACH FOR DEVELOPMENT OF MICROEMULSION CONTAINING PASSIFLORA SETACEA OIL

KEY WORDS:

Emulsified system; natural oil; experimental design

PAGES: 79
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Microemulsions are nanoscale systems, particularly between 10 and 100 nm, capable of transporting natural oils and improving their organoleptic characteristics. The fixed oil obtained from Passiflora setacea stands out among others for its composition rich in unsaturated fatty acids of the omega family, endowed with therapeutic potential, such as wound healing. Thus, the aim of this work was to use the ideals of QbD for the development of a formulation based on microemulsified systems. Initially, the fixed oil from P. setacea seeds was extracted using the Soxhlet method and had its chemical composition characterized using GC-MS. Then, designs of experiments were used to identify the ideal composition of oil, surfactants, and ratio of surfactants in relation to hydrodynamic droplet diameter, polydispersity index and visual classification. The exploratory linear planning models were not significant, indicating the possible presence of curvature. The Box-Behnken design was satisfactory in predicting the influence of factors and their interactions, the model has r2 of 0.99, 0.91 and 0.97, for hydrodynamic diameter, PDI and visual classification, respectively. Through the response surface and the desirability profile, it was possible to develop an optimized system, followed by its improvement for the topical route. These systems retained their physicochemical stability for 60 days, with a good prognosis to be further investigated for activity and toxicity.

BANKING MEMBERS:
Interno - 346138 - ALDO DA CUNHA MEDEIROS
Presidente - 1178187 - ERYVALDO SOCRATES TABOSA DO EGITO
Externo à Instituição - HENRIQUE RODRIGUES MARCELINO - UFBA