Banca de DEFESA: DÉBORA BATISTA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : DÉBORA BATISTA
DATE: 25/10/2021
TIME: 09:30
LOCAL: DEFESA REMOTA - https://meet.google.com/xvq-roxy-cgg
TITLE:

TOXICOLOGICAL AND MUTAGENIC EVALUATION OF THE AQUEOUS EXTRACT OF Licania rigida BENTH LEAVES IN ASSOCIATION WITH PROTECTIVE EFFECTS ON OXIDATIVE STRESS.


KEY WORDS:

Medicinal plants; toxicity; oxidative stress; herbal.


PAGES: 62
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Medicinal plants present bioactive substances that help in the treatment of the most diverse diseases and their use for therapeutic purposes is as old as human civilization. In Brazil, the use of medicinal plants for primary health care is widespread due to its large plant biodiversity, low cost, easy access, and wide popular knowledge about their use. However, it is worth noting that most species used in traditional medicine do not present scientific studies proving their efficacy, safety, chemical composition, or possible toxicity. In this context, the species Licania rigida Benth belonging to the Chrysobalanaceae family is a plant species found in the semiarid northeastern Brazil, being used in folk medicine for the treatment of inflammatory processes and diabetes. However, despite its use, there are few studies to validate its pharmacological and toxicological potential. As a result, the objective of this study was to evaluate the toxicological properties of the aqueous extract of Licania rigida through standardized methods of acute and subchronic oral toxicity, mutagenicity and cytotoxicity, as well as its possible protective effect against oxidative stress. The extract did not show any toxic or genotoxic effect in the in vivo and in vitro assays after exposure to different concentrations. Regarding the antioxidant effect, the extract exhibited a possible protective effect by decreasing the level of malondialdehyde (MDA) in the treated animals; no considerable change was observed for the levels of reduced glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPX). Therefore, it is proposed that Licania rigida leaf extract may become a future herbal medicine, however, further studies are needed to validate its pharmacological application and for the development of new herbal formulations. 


BANKING MEMBERS:
Externa à Instituição - HERYKA MYRNA MAIA RAMALHO - UNP
Externa ao Programa - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Presidente - 346847 - MARIA DAS GRACAS ALMEIDA THORNTON
Notícia cadastrada em: 15/10/2021 19:03
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