Banca de DEFESA: LANA SARITA DE SOUZA OLIVEIRA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LANA SARITA DE SOUZA OLIVEIRA
DATE: 18/10/2021
TIME: 14:30
LOCAL: DEFESA REMOTA - https://meet.google.com/tpz-bphh-sey
TITLE:

COMPARISON OF CRYPTOCOCCUS GATTII/NEOFORMANS SPECIES COMPLEX TO RELATED GENERA (PAPILIOTREMA AND NAGANISHIA) REVEAL VARIANCES IN VIRULENCE ASSOCIATED FACTORS AND ANTIFUNGAL SUSCEPTIBILITY.

KEY WORDS:

Cryptococcus spp., Papiliotrema laurentii, Naganishia spp., virulence factors, antifungal drug susceptibility.

PAGES: 17
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Cryptococcosis is an infectious disease of worldwide distribution, caused by encapsulated yeasts belonging to the phylum Basidiomycota. The genus Cryptococcus includes several species distributed around the world. The C. gattii/neoformans species complex is largely responsible for most cases of cryptococcosis. However, clinical series have been published of infections caused by Papiliotrema (Cryptococcus) laurentii and Naganishia albida (Cryptococcus albidus), among other related genera. Here, we examined the pathogenic potential and antifungal susceptibility of Cryptococcus spp. and related genera isolated from environmental and clinical samples. P. laurentii and Naganishia spp. strains produced higher levels of phospholipase and hemolysins, whereas the C. gattii/C. neoformans species complex strains had markedly thicker capsules, produced more biofilm biomass and melanin, which are known virulence attributes. Interestingly, more strains of non-C. gattii/C. neoformans species complex exhibited non-wild type phenotypes in response to fluconazole, itraconazole and amphotericin B. Finally, all the non-C. gattii/C. neoformans clinical isolates produced more melanin and this might reflect their particularly enhanced need for melanin during in vivo protection. It is very clear that clades I and II strains, in general, show more similar virulence phenotypes among each other when compared to clades III to V isolates and vice versa. These findings, together with the fact that P. laurentii and Naganishia spp. strains were collected from the outside of a University Hospital, may be important for environmental and patient colonization and further risk for infections.

BANKING MEMBERS:
Externa à Instituição - DANIELLE PATRICIA CERQUEIRA MACEDO
Interna - 2323511 - ADRIANA AUGUSTO DE REZENDE
Interna - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Presidente - 1715308 - GUILHERME MARANHAO CHAVES
Externo à Instituição - TEREZINHA INEZ ESTIVALET SVIDZINSKI - UEM