Banca de QUALIFICAÇÃO: GALTIERI OTAVIO CUNHA DE MEDEIROS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : GALTIERI OTAVIO CUNHA DE MEDEIROS
DATE: 13/10/2021
TIME: 14:30
LOCAL: DEFESA REMOTA - https://meet.google.com/vqs-gjuy-fuv
TITLE:

COMPARATIVE ASSESSMENT OF ABDOMINAL VERSUS THIGH MUSCLE CHARACTERISTICS USING COMPUTED TOMOGRAPHY IMAGES

KEY WORDS:

Low muscle mass, sarcopenia, body composition, muscle quality, muscle radiodensity, muscle attenuation.

PAGES: 11
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Background: Studies evaluating low muscle mass (or sarcopenia) by computed tomography (CT) images often evaluate the third lumbar vertebrae (L3). However, lower limbs appendicular muscles are more involved in balance, physical function, locomotion, and daily activities. Objective: This study aimed to compare the assessments of skeletal muscle area (SMA in cm²), skeletal muscle index (SMI in cm²/m²) and skeletal muscle density (SMD in HU) between these two landmarks, and the agreement in diagnosing muscle abnormalities (L3 as the reference method). Methods: Multicenter cross-sectional study including healthy individuals (≥ 18 years old) of both sexes, who performed an elective CT exam including abdominal and pelvic regions. CT images were analyzed to evaluate SMA, SMI and SMD. Muscle abnormalities (low SMA, SMI, and SMD) were defined as the 5th percentile from a subsample of young adults. Correlation coefficients, Bland-Altman graphs, Kappa coefficients (k), percentage of the agreement, and receiver operating characteristic (ROC) curves were calculated for the total sample and stratified by sex and age. Results: 268 individuals (44.3 ± 15.2 years) were evaluated (53% female). Significant (p <0.001 for all analysis) and strong correlations between SMA (rho = 0.896), SMI (rho = 0.853), and SMD (rho = 0.864) from L3 and thigh were observed. Weak (k=0.501 for SMI) to moderate (k=0.645 for SMD) agreements were observed for the diagnoses of muscle abnormalities between the two landmarks. Sub analysis showed better results for males and young adults. Conclusions: Muscle characteristics between L3 and thigh landmarks have a strong correlation but weak to moderate agreements. Muscle quantity (SMA and SMI) and quality (SMD), both in L3 and in the thigh, differ by age and sex. It is possible that SMD at the L3 may show earlier changes in muscle characteristics, enabling early interventions, but longitudinal studies are needed to confirm this hypothesis.

BANKING MEMBERS:
Presidente - 1879430 - ANA PAULA TRUSSARDI FAYH
Externo à Instituição - JOSE BARRETO CAMPELLO CARVALHEIRA
Externa à Instituição - RENATA MORAES BIELEMANN - UFPel