Banca de DEFESA: EVELLYN CÂMARA GRILO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : EVELLYN CÂMARA GRILO
DATE: 29/09/2021
TIME: 14:30
LOCAL: DEFESA REMOTA - https://meet.google.com/mfx-vqvt-cqb
TITLE:

BODY COMPOSITION OF PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY AND THE EFFECT OF ZINC SUPPLEMENTATION ON BONE PARAMETERS IN THIS POPULATION.

KEY WORDS:

Body composition, DXA, zinc, bone health, muscular dystrophies.

PAGES: 79
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Duchenne Muscular Dystrophy (DMD) is a neuromuscular disease that results in progressive muscle atrophy. The available therapy to slow the progression of DMD is the use of steroids. However, this therapy has side effects, including changes in body composition, growth deficit and bone demineralization. Methods for assessing the nutritional status of the healthy population may be imprecise and inapplicable for the population with DMD. In addition, the assessment and management of bone health is important for the population with DMD. Zinc is an important micronutrient for bone health and no studies were found involving zinc supplementation in patients with DMD. Given these health demands of the population with DMD, this doctoral thesis had as its main objectives: to verify the validity of the BIA as a practical method for assessing body composition in patients with DMD and to investigate the effect of supplementation with zinc on the serum zinc and bone parameters in this population. To this end, two studies were carried out: the first observational cross-sectional study including 46 patients with DMD (Study 1) and the second study with an interventional design nested within a cohort including 34 patients with DMD (Study 2). The studies were carried out at Neurology Outpatient facility at HUOL in Natal/RN. The main finding of Study 1 was that BIA is a viable method to estimate % fat-free mass (%FFM) in children and adolescents with DMD. Among the eight predictive equations evaluated, five equations were accurate to estimate %FFM by BIA in patients with DMD, respecting the age range of each equation. The main findings of Study 2 were that oral zinc supplementation increased serum zinc levels in DMD patients who had prior deficiency. However, zinc supplementation had no effect on bone density and mineral content of patients with DMD. These studies will serve as a basis for the assessment of body composition using BIA in patients with DMD and for possible interventions with zinc in patients with DMD who are deficient in this micronutrient.

BANKING MEMBERS:
Externa à Instituição - FATIMA APARECIDA CAROMANO
Externo à Instituição - DÉBORA KURRLE RIEGER VENSKE
Interna - 175.476.444-49 - LUCIA DE FATIMA CAMPOS PEDROSA - UFRN
Externa ao Programa - 4659679 - SANCHA HELENA DE LIMA VALE
Externa ao Programa - 1452705 - SEVERINA CARLA VIEIRA CUNHA LIMA