Banca de DEFESA: JEFFERSON ROMÁRYO DUARTE DA LUZ

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JEFFERSON ROMÁRYO DUARTE DA LUZ
DATE: 30/08/2021
TIME: 09:30
LOCAL: DEFESA REMOTA - meet.google.com/ekw-sbto-rum
TITLE:

CHEMICAL AND TOXICOLOGICAL CHARACTERIZATION OF EXTRACTS OBTAINED FROM VEGETABLE SPECIES FROM THE CAATINGA BIOMA AND ITS EFFECTS ON INFLAMMATORY RESPONSE AND HEMOSTASIS

KEY WORDS:

Phenolic compounds; toxicity; Blood coagulation; Inflammation.

PAGES: 95
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Inflammation is composed of a vascular and a cellular reaction, conferring different tissue and cell reactions, both in the intravascular and extravascular environments. As the inflammatory process occurs, coagulation proteases, especially thrombin (FIIa), can trigger several cellular responses in vascular biology and, therefore, activation of other biological systems is often observed, leading to complications during an event inflammatory, such as thrombosis. Thus, molecules that positively interfere in these events are interesting models for the development of new anti-inflammatory drugs. In this context, secondary metabolites of medicinal plants stand out, which interact with several proteins involved in important biological processes, including inflammation and coagulation. For this reason, this study aimed to chemically and toxicologically characterize the plant extracts of two species of the Caatinga Biome (Turnera subulata and Licania rigida Benth), as well as to evaluate the anti-inflammatory and anticoagulant potentials of the extracts. The extracts were obtained from the collection and drying of plant material with subsequent aqueous and alcoholic extraction, being then rotaevaporated and lyophilized. Turnera subulata and Licania rigida Benth extracts showed flavonoids as the main phytocomponents and low toxicity, in addition to showing an interesting anticoagulant effect by APTT, PT, direct inhibition of thrombin and indirect inhibition through heparin cofactor II. On inflammation, the extracts showed a significant inhibitory effect with a reduction of pro-inflammatory cytokines (TNF-α and IL-1β) and a stimulatory effect on IL-10, in addition to being able to reduce prostaglandin E2 and nitric oxide. Thus, the results exhibited by the extracts point to these as a pharmacological target with perspectives for the development of new anti-inflammatory drugs.

BANKING MEMBERS:
Externa à Instituição - ANELISE SAMARA NAZARI FORMAGIO - UFGD
Externo à Instituição - DAMIAO PERGENTINO DE SOUSA
Externo ao Programa - 1149356 - ELIZEU ANTUNES DOS SANTOS
Presidente - 346847 - MARIA DAS GRACAS ALMEIDA THORNTON
Externo ao Programa - 2962496 - RAFAEL BARROS GOMES DA CAMARA