Banca de QUALIFICAÇÃO: KLEYTON SANTOS DE MEDEIROS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : KLEYTON SANTOS DE MEDEIROS
DATE: 16/07/2021
TIME: 14:00
LOCAL: DEFESA REMOTA - https://meet.google.com/kvx-stku-uer
TITLE:

IMPACT OF SARS-COV-2 (COVID-19) ON PREGNANCY AND NEWBORN: A SYSTEMATIC REVIEW AND META-ANALYSIS 


KEY WORDS:

SARS-CoV-2; COVID-19; Pregnancy; Newborn. 


PAGES: 25
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Background

The COVID-19 pandemic, caused by the sars-CoV-2 virus, has been overgrowing and has become a public health emergency. In addition, pregnant women and their fetuses are susceptible to viral infection, and outcomes in this population need to be investigated.

Objective

To clarify the clinical features of COVID-19 and analyze maternal and fetal morbidity and mortality and the obstetric and neonatal outcomes of pregnant patients with COVID-19.

Methods

A systematic review with meta-analysis was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search of bibliographic databases and grey literature was conducted from December 2019 to March 2021. The following databases were accessed: Embase, PubMed, Web of Science, CINAHAL, LILACS, Google Scholar and Scopus. The risk was assessed using the Newcastle-Ottawa Scale for observational studies. To evaluate the strength of evidence from the included data, we used the Grading of Recommendation Assessment, Development, and Evaluation method (GRADE). Data synthesis was performed using Review Manager software V.5.2.3. To assess heterogeneity, we computed the I2 statistics. Additionally, qualitative synthesis was performed of the included studies.

Results

Seventy-four articles were included involving 10047 pregnant women with COVID-19 and 2014 newborns.

 Pregnant women were in the third trimester of pregnancy in 53 studies (71.6%). The most common symptoms were: fever, cough, chest pain, dyspnea, nasal congestion, sore throat, headache, myalgia, anosmia, ageusia, nausea, vomiting, diarrhea, tachypnea, tachycardia, fatigue, and oxygen desaturation. The primary type of delivery was cesarean (89%) and preterm. There were 46 deaths and only two abortions. Ventilatory support (15%), admission to the ICU (12%), and pneumonia (92%) were unfavorable outcomes. Lymphopenia, increased CRP, and liver was found in 85% of pregnant women. Of the neonatal outcomes: premature neonates (32%), APGAR less than 7 (28%), stillbirth (0.3%), admission to the NICU (36%), and fetal stress (2%) were more prevalent. There is no evidence of COVID-19 in the placenta, breast milk, umbilical cord, and amniotic fluid, except for two studies that evidenced it in amniotic fluid.

Conclusion

Pneumonia, admission to the ICU, use of ventilatory support, and death were the outcomes found. However, the course of the disease in pregnant women appears to be similar to non-pregnant women. The diagnosis of COVID-19 may influence the increase in preterm and cesarean deliveries. Vertical transmission and breast milk were not explicitly highlighted.

 

PROSPERO registration: CRD42020181519.


BANKING MEMBERS:
Presidente - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Interna - 2323511 - ADRIANA AUGUSTO DE REZENDE
Interno - 1178187 - ERYVALDO SOCRATES TABOSA DO EGITO
Notícia cadastrada em: 15/07/2021 15:55
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