Banca de DEFESA: MARCO AURÉLIO VIANELLO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : MARCO AURÉLIO VIANELLO
DATE: 16/12/2020
TIME: 14:00
LOCAL: DEFESA REMOTA - https://meet.google.com/haa-twof-sfa
TITLE:

BACTERIAL RESISTANCE TO FLUORQUINOLONES IN INDIGENOUS INDIVIDUALS FROM THE BRAZILIAN AMAZON

KEY WORDS:

ExPEC, ciprofloxacin-resistant, multidrug-resistant, Enterobacterales, fecal carriage

PAGES: 18
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

The global dissemination of multidrug-resistant Escherichia coli lineages belonging to high- risk clones poses a significant public health threat. Herein we report the identification and genomic profiling of two multidrug-resistant E. coli strains [BL-II-03(2) and BL-II-11(3)] belonging to the O15:H1‐ D‐ ST393 (clonal complex 31) worldwide spread clone, isolated from fecal samples of indigenous peoples belonging to two different ethnic groups of remote communities of Brazilian Amazon. Agreement of genotype-phenotype prediction of antimicrobial resistance was confirmed. In this regard, genomic analysis revealed genes and mutations conferring resistance to β-lactams [bla EC , bla TEM-1 ], aminoglycosides [aadA5, aph(3'')-Ib, aph(6)-Id], tetracyclines [tetB], sulfamethoxazole/trimethoprim [sul1, sul2, dfrA17], and fluoroquinolones [gyrA (D87N, S83L), parC (S80I, S57T), parE (L416F)]. On the other hand, phylogenomics of globally reported E. coli ST393 assigned E. coli strains BL- II-03(2) and BL-II-11(3) to a cluster comprising human isolates from Australia, Canada, China, Sweden, and United States of America. These results might provide valuable information for understanding dissemination of intercontinental multidrug-resistant clones in remote communities with low levels of antibiotic exposure.

BANKING MEMBERS:
Externo à Instituição - ALESSANDRO CONRADO DE OLIVEIRA SILVEIRA
Externo à Instituição - RODRIGO DE ALMEIDA VAUCHER
Interno - 2087759 - ANDRE DUCATI LUCHESSI
Presidente - 1178187 - ERYVALDO SOCRATES TABOSA DO EGITO
Interno - 1715308 - GUILHERME MARANHAO CHAVES