Banca de DEFESA: JEANE FRANCO PIRES MEDEIROS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JEANE FRANCO PIRES MEDEIROS
DATE: 11/12/2020
TIME: 09:00
LOCAL: DEFESA REMOTA - https://meet.google.com/ctx-vdhu-qzo
TITLE:

EVALUATION OF VITAMIN D SUPPLEMENTATION IN GENE EXPRESSION AND PHYSICAL FITNESS IN TWINS

KEY WORDS:

Cholecalciferol; Vitamin D Receptors; Body Composition; Cardiorespiratory Fitness; Muscle Strength; Clinical Trial.

PAGES: 29
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

The presence of the vitamin D receptor in various human cells and tissues, relating vitamin D to several non-skeletal physiological processes has been generating interest in research that helps to better understand this relationship.  In addition, prophylactic supplementation with this nutrient is growing every day, in all age groups. Thus, the aim of this study was to evaluate the effect of vitamin D3 supplementation on VDR gene expression, body composition, cardiorespiratory fitness and muscle strength in healthy adults. It was a study carried out in adult monozygotic twins, of the longitudinal randomized clinical trial type, divided into two groups: control group (without treatment) and supplemented group (with individual daily supplementation of 2000 IU / day of vitamin D3 for 60 days). Biochemical analyzes, body composition analyzes were performed using double beam absorptiometry, analysis of cardiorespiratory fitness in a Cortex Ergospirometer, evaluation of muscle strength by the handgrip and scapular strength test and gene expression by real-time PCR.  The statistical analysis was performed using the statistical software IBM SPSS version 20.0 for Windows. Our results showed that there was a significant increase in serum vitamin D levels in the supplemented group compared to those who did not use the supplement. (65% increase), as well as the expression of the VDR gene (p = 0.001). We observed improvements in physical fitness parameters, with reduced body fat and increased VO2max after supplementation. Thus, we conclude that the increase in serum vitamin D levels above 30 ng / mL can bring benefits to the health of the population.

BANKING MEMBERS:
Presidente - 2087759 - ANDRE DUCATI LUCHESSI
Interno - 2626634 - PAULO MOREIRA SILVA DANTAS
Externa ao Programa - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Externa à Instituição - MARIA DA CONCEICAO RODRIGUES GONCALVES
Externo à Instituição - RAUL HERNANDES BORTOLIN - USP