Banca de DEFESA: ITALO MEDEIROS DE AZEVEDO
Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.STUDENT : ITALO MEDEIROS DE AZEVEDO
DATE: 30/10/2020
TIME: 09:00
LOCAL: DEFESA REMOTA - https://meet.google.com/viv-pxyn-qaq
TITLE:
DIAGNOSTIC ACCURACY OF 18F-FDG-PET IN ABDOMINALSEPSIS IN RATS
KEY WORDS:
Sepsis. Septic foccus. Diagnostic. 18F-FDG. Rats. ROC Curve
PAGES: 54
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:
Objective: The objective of this study was to investigate the accuracy of 18F-FDG-PET in the diagnosis of multibacterial abdominal sepsis by ligation and puncture of the cecum in rats. Methods: Adult male rats (Rattus norvegicus) from the Wistar strain, weighing 227±35g, were divided into a sepsis group by ligation and puncture of the cecum (n = 10) and control (n = 10). Positron emission tomography using microPET was performed on all rats after 24 hours of observation. Results: Results: All animals survived until the end of the observation period. The ratio of the SUV percentage captured in the abdomen and liver was significantly higher in the sepsis group than in the control group (p=0.004). The ROC curve showed an accuracy of 18F-FDG-PET to detect abdominal sepsis of 88.9% (p=0.001), with a sensitivity of 90% and a specificity of 88.9%. When a cut-off point of 79% of the ratio between the uptake on the abdominal region and liver was established, the sensitivity was 90%, specificity of 88.9%; positive and negative predictive values of 90.0% and 88.9%, respectively. Conclusion: In conclusion, the diagnostic accuracy of 18F-FDG-PET in rats with abdominal sepsis was very high. It also demonstrated the predictive ability of the uptake relationship between the infected area and the liver. It can be useful to locate abdominal septic foci by using full body screening.
BANKING MEMBERS:
Presidente - 346138 - ALDO DA CUNHA MEDEIROS
Externa à Instituição - AMALIA CINTHIA MENESES DO REGO - UnP
Externo à Instituição - CIPRIANO DA CRUZ FORMIGA - EBSERH
Externo ao Programa - 3328363 - FRANCISCO IROCHIMA PINHEIRO
Externo ao Programa - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR