Banca de DEFESA: LENILTON SILVA DA SILVEIRA JUNIOR

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LENILTON SILVA DA SILVEIRA JUNIOR
DATE: 26/10/2020
TIME: 08:00
LOCAL: DEFESA REMOTA - https://meet.google.com/cay-xsng-tfr
TITLE:

STUDY OF ACUTE MYELOID LEUKEMIAS: CELL MARKERS AND PROGNOSTIC FACTORS.

KEY WORDS:

Acute myeloid leukemia; Cellular markers; Prognostic factors.

PAGES: 10
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Acute myeloid leukemia (AML) is a clonal disease of hematopoietic tissue and accounts for 80% of leukemia cases in adults. It is divided into seven subtypes (M0 to M7), according to the classification of the Franco-American-British group. Despite great advances in chemotherapy, there are still cases of acute leukemias refractory to treatment or recurrence of the disease, triggered by mechanisms of multiple drug resistance (MDR), with the extrusion of chemotherapy agents by drug efflux pumps, one of the main mechanisms. The analysis of glycoprotein P (PgP) and protein associated with resistance to multiple drugs (MRP), by flow cytometry, was the target of this study, which showed that both the expression of both was prevalent in older patients and the incidence was showed greater in cases of refractoriness, recurrence and secondary disease when compared to cases of AML “de novo”. The use of these markers as a parameter of the MDR profile helps in the diagnosis and treatment of acute leukemias, in addition to being a prognostic marker for patients with AML.

BANKING MEMBERS:
Externo ao Programa - 346138 - ALDO DA CUNHA MEDEIROS
Externa à Instituição - AMALIA CINTHIA MENESES DO REGO - UnP
Externa ao Programa - 1375489 - ANA CLAUDIA GALVAO FREIRE GOUVEIA
Externo à Instituição - CARLOS ROBERTO ALVES - Fiocruz - RJ
Presidente - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR