Banca de QUALIFICAÇÃO: RÔMULO DOS SANTOS CAVALCANTE

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : RÔMULO DOS SANTOS CAVALCANTE
DATE: 19/06/2020
TIME: 09:00
LOCAL: QUALIFICAÇÃO REMOTA - https://meet.google.com/phv-rzvb-eio
TITLE:

M2-LIKE TAM VIA STAT3/NF-ΚB SIGNALING AXIS AS TARGET OF IMMUNOMODULATORY THERAPY WITH HA-COATED PEIPLGA-MTX NANOPARTICLES AND ANTI-PD-L1 CHECKPOINT BLOCKER IN THE BREAST CANCER

KEY WORDS:

Immunomodulation, PLGA nanoparticles, STAT3, NF-kB, tumor microenvironment

PAGES: 47
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

 

Inflammation associated with the tumor microenvironment plays a critical role in the growth and progression of cancer, and immunotherapeutic strategies that aim to modulate the immune response in cancer have been crucial. In this study, a PLGA-based drug nanocarrier covered with polyethyleneimine (Pei) and hyaluronic acid (HA) was developed and associated with an anti-PD-L1 immune checkpoint inhibitor to investigate the anti-cancer and immunomodulatory performance in the breast cancer. From the allographic tumor induction model, the combined therapy altered tumorigenic course as well as promoting immunomodulation in tumor microenvironment with a significant reduction in primary tumor and metastasis. For the first time, our findings suggest the presence of an IL-10-STAT3-NF-κB signaling axis mediated by M2 macrophage in breast cancer. Importantly, the triggered NF-κB/STAT3-mediated signaling suppression by our treatment seems to have disrupted the communication between immune and cancer cells, reducing critical pro-tumor events such as: immune escape; cell survival; drug and apoptosis resistance, as well as some key mechanisms in EMT. These results contribute to our understanding of the immunological mechanisms that underlie the anti-tumorigenic effects of an effective and promising drug nanocarrier capable of satisfactorily immunomodulating the tumor microenvironment and providing a favorable outcome in breast cancer.

BANKING MEMBERS:
Presidente - 2329140 - RAIMUNDO FERNANDES DE ARAUJO JUNIOR
Interno - 1178187 - ERYVALDO SOCRATES TABOSA DO EGITO
Externa ao Programa - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS