Banca de QUALIFICAÇÃO: JEANE FRANCO PIRES MEDEIROS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : JEANE FRANCO PIRES MEDEIROS
DATE: 10/12/2019
TIME: 14:30
LOCAL: Sala de aula do PPGCF
TITLE:

Vitamin D supplementation associated with mRNA gene expression in monozygotic twins


KEY WORDS:

Cholecalciferol; Micronutrients; Genetics; Genotype.


PAGES: 29
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Vitamin D supplementation is widely used at maintenance doses. This micronutrient is related to several functions in the body, since vitamin D receptors (VDR) can be found in many cell types, however, the benefits that this supplementation can bring to health are not clear. Gene expression is influenced by individual genetics, thus twin research aims to narrow these differences in phenotypic responses. In our short-term longitudinal clinical trial we showed that supplementation with cholecalciferol at the concentration of 2000 IU in monozygotic twins (male or female pairs) increased serum vitamin D concentration by 65% and VDR gene expression sixty times (p = 0.001), but did not influence the expression of Tumor Necrosis Factor Alpha (TNFa) or Peroxisome Proliferator Activated Receptor Alpha (PPARa) genes (p = 0.679 and p = 0.730, respectively). In addition, no changes in body composition parameters were observed, suggesting that a higher concentration and supplementation time are necessary to induce changes in these variables. Our results indicate that an increase in serum vitamin D concentration may have potential therapeutic implications.


BANKING MEMBERS:
Presidente - 2087759 - ANDRE DUCATI LUCHESSI
Externa ao Programa - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Interno - 2626634 - PAULO MOREIRA SILVA DANTAS
Notícia cadastrada em: 28/11/2019 11:14
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