Banca de QUALIFICAÇÃO: RALFO CAVALCANTI DE MEDEIROS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : RALFO CAVALCANTI DE MEDEIROS
DATA : 16/05/2019
HORA: 09:00
LOCAL: sala de aula do PPGCSa
TÍTULO:

INVESTIGATION OF EPIDEMIOLOGICAL AND GENOTYPICAL FACTORS OF VIRAL HEPATITIS C IN RIO GRANDE DO NORTE, BRAZIL

PALAVRAS-CHAVES:

Hepatitis C Virus, Epidemiology;

PÁGINAS: 37
GRANDE ÁREA: Ciências Biológicas
ÁREA: Farmacologia
RESUMO:

INTRODUCTION: Hepatitis due to hepatitis C virus affects around 180 million people worldwide. It is estimated that in Brazil between 1% and 3% of the population are contaminated, and the majority are unaware of this diagnosis. Without specific symptoms, hepatitis C evolves inconspicuously for decades. In addition to the development of cirrhosis, it presents marked morbidity and mortality due to its decompensation and eventual evolution to hepatocellular carcinoma, being the most frequent cause of liver transplantation indication. To determine the epidemiological characteristics of patients infected with Hepatitis C virus in Rio Grande in the North. METHODS: A prospective analysis was performed on 466 samples of patients with chronic hepatitis C treated at the Central Public Health Laboratory of Rio Grande do Norte between 2012 and 2016. The identification of HCV genotypes was performed by direct sequencing of the 5 'UTR region, followed of comparative analysis by alignment of sequences obtained by RT PCR. In addition, a phylogenetic analysis of variants obtained within each genotype was performed. RESULTS: Of the total analyzed, 297 were males and 169 females. The age range ranged from 22 to 86 years (median 50). The frequencies of the genotypes were: g1b (n = 257), g1a (n = 111), g3 (n = 76), g2 (n-21) and g4 (n = 3). Co-infection with hepatitis A (n = 38), hepatitis B (n = 34), human immunodeficiency virus (n = 10), chagas disease (n = 2), syphilis 3), cytomegalovirus (n = 7). Other pathogens such as toxoplasmosis, schistosomiasis, tuberculosis and leishmaniasis were observed in one case each. CONCLUSIONS: Because of the prevalence found, the hepatitis C virus infection in the municipality is slightly higher than that reported by other studies in other regions of Brazil, with an age group suggesting infection in the recent past. Public policies to identify infected individuals need to be intensified to contain the transmission of this infectious agent. Public policies to identify infected individuals need to be intensified to contain the transmission of this infectious agent.

MEMBROS DA BANCA:
Externo à Instituição - ALDAIR DE SOUSA PAIVA - UFRN
Externa ao Programa - 1375489 - ANA CLAUDIA GALVAO FREIRE GOUVEIA
Presidente - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR