Banca de DEFESA: LUCIANA MAGALHÃES PINTO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : LUCIANA MAGALHÃES PINTO
DATA : 20/12/2018
HORA: 09:00
LOCAL: sala de aula do PPGCSa
TÍTULO:

Candida species isolated from pigeon (Columbia livia) droppings may express virulence factors and resistance to azoles

PALAVRAS-CHAVES:

Candida spp, virulence factors, antifungal resistance, pigeon droppings, Columbia livia

PÁGINAS: 22
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Even though it is widely known that Cryptococcus spp. may transmit cryptococcosis trough aerosol formed when dried birds (mainly pigeons) droppings are dispersed and become airborne, little is known about the role of these birds in harboring other pathogenic yeasts in their gastrointestinal tract, feathers and beaks, specifically because these animals often stay and reproduce close or even above air conditioner units. Here we evaluated the prevalence of pathogenic yeasts isolated from pigeon droppings collected in the outside area of a University Hospital in Brazil. We also aimed to investigate the pathogenic potential and antifungal susceptibility of Candida species of medical interest isolated from these samples. Therefore, we performed the evaluation of virulence factors attributes expression in vitro, including the ability to adhere to human buccal epithelial cells and biofilm formation and to produce lytic enzymes, such as phospholipases, proteinases and hemolysins. Antifungal susceptibility testing against fluconazole, itraconazole, amphotericin and micafungin was also performed. The Candida genus was the most prevalent in our study, with several medically important species being isolated. Of note, these strains were able to express several virulence factors in vitro, clearly showing their pathogenic potential. Our study was able to demonstrate that Candida spp. isolated from pigeon droppings may express virulence factors in the same manner of clinical isolates, suggesting a pathogenic potential for these yeasts. The fact these strains were collected from the outside area of a tertiary hospital may be of interest, because they may be a source of infection, specifically to immunocompromised hosts.

MEMBROS DA BANCA:
Externo ao Programa - 1149398 - EVELINE PIPOLO MILAN
Presidente - 1715308 - GUILHERME MARANHAO CHAVES
Externo à Instituição - RAQUEL DE MELO BARBOSA
Externo à Instituição - WALICYRANISON PLINIO DA SILVA