Banca de QUALIFICAÇÃO: ROBERTO MORENO MENDONCA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : ROBERTO MORENO MENDONCA
DATA : 05/11/2018
HORA: 14:00
LOCAL: sala de aula do PPGCSa
TÍTULO:

ROLE OF BREAST VASCULAR CALCIFICATION IN PREDICTING

CARDIOVASCULAR RISK


PALAVRAS-CHAVES:

Women's Health; Mammography; Vascular Calcification; Computed tomography;

Atherosclerosis; Cardiovascular Diagnostic Techniques; Coronary artery disease


PÁGINAS: 20
GRANDE ÁREA: Ciências da Saúde
ÁREA: Medicina
RESUMO:

Cardiovascular diseases (CVD) are the leading cause of death worldwide among women, resulting in 8.6 million deaths annually. Computed tomography (CT) has been used to evaluate the coronary arteries calcifications by quantifying the Coronary Calcium Score (CCS), validated as marker of cardiovascular risk. Additionally, mammography is the only method for population screening of breast cancer, but also could identify atherosclerosis, known as breast vascular calcification (BVC). We verified if there is an association between the BVC and high CCS, thus predicting cardiovascular risk in women whose mammograms revealed BVC.

An observational, analytical study included women submitted to mammography and CCS-CT. Patients with incomplete exams or interval over 12 months were excluded. A systematic random sampling was employed to select the 51 patients, retrieved and reassessed for the presence of BVC and CCS. Being pilot study, sample size was based on convenience, preserving randomness. Aggravating factor of cardiovascular risk was considered to be a CCS greater than 100 (Agatston Score) and/or percentile above 75%. Being pilot study, sample size was based on convenience, preserving randomness. Aggravating factor of cardiovascular risk was considered to be a CCS greater than 100 (Agatston Score) and/or percentile above 75%. The mean age was 56.47(±9.16) years. Of the 51 patients, 16(31.4%) presented and 35(68.6%) did not present BVC on mammograms. In regard to the CCS evaluation, 14(27.4%) of patients presented values> 100 and/or percentile> 75%, and 37(72.6%) presented CCS below this cut off. In patients who did not present BVC, it was observed that 29(83.0%) presented CCS compatible with low cardiovascular risk. In patients with BVC, there was equal distribution between the CCS considered low and high cardiovascular risk (8 subjects each group). The prevalence of high cardiovascular risk among exposed individuals (BVC present) was 50.0%, while the prevalence among the non-exposed (BVC absent) was 17.1%, with a prevalence ratio=2.91 and prevalence OR=4.83 (P=0.015, CI95%=1.07-22.1), confirming the positive association. Additionally, specificity of 82.9% was observed, together with negative predictive value of 78.4%, and accuracy of 72.5%. In our preliminary study, positive association between mammary vascular calcifications and the coronary calcium score is evident. Absence of BVC is statistically associated with low cardiovascular risk and may directly reflect a less intense atherosclerotic process.


MEMBROS DA BANCA:
Presidente - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Externo ao Programa - 1451614 - JOSIVAN GOMES DE LIMA
Externo ao Programa - 2495713 - ROSIANE VIANA ZUZA DINIZ
Notícia cadastrada em: 01/11/2018 12:00
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