Banca de DEFESA: DANIELE MARIA LOPES PINHEIRO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : DANIELE MARIA LOPES PINHEIRO
DATA : 09/11/2019
HORA: 14:00
LOCAL: Centro de Biociências
TÍTULO:

Resveratrol regulates inflammatory response through chromatin remodeling


PALAVRAS-CHAVES:

Oxidative stress and inflammation are correlated in a great number of pathologies playing a relevant role as therapeutic target. Many research have attempted to use polyphenols, such as Resveratrol (trans–3,4’,5–trihydroxystilbene), a phytoalexin polyphenol found in various plants, to reduce inflammatory response which becomes an interesting adjuvant therapy mainly during infectious and neurodegenerative diseases. Evidences indicate this compound with different beneficial effects contribute to the health and homeostasis of the organism. In order to better elucidate how resveratrol regulate inflammation, this study aimed to reveal the global gene transcription change that occurs during the inflammatory response in the presence of Resveratrol. Genome-wide RNA sequencing showed differential expression in the total global genes including 3025 upregulated and 5645 downregulated genes. Gene ontology and protein–protein interaction analyses indicated that the upregulated genes were related to transcription, metabolic processes, imune system and cell cycle. The downregulated genes comprised genes involved in the inflammatory response, cell cycle and transcription. Our transcriptome comparison with analysis in vitro showed us that Resveratrol works controlling epigenetic changes. Was observed this compound acts on the general pattern of acetylation and APE1/Ref-1 protein, decreasing the expression of inflammatory modulators, as well as the protein expression of p65 (NFKB).


PÁGINAS: 235
GRANDE ÁREA: Ciências da Saúde
ÁREA: Medicina
RESUMO:

Resveratrol, Antioxidant, Inflammation, Chromatin, Transcription


MEMBROS DA BANCA:
Externo ao Programa - 1549705 - ADRIANA FERREIRA UCHOA
Externo à Instituição - ANDRE QUINCOZES DOS SANTOS - UFRGS
Presidente - 1149647 - LUCYMARA FASSARELLA AGNEZ LIMA
Externo ao Programa - 1507794 - RODRIGO JULIANI SIQUEIRA DALMOLIN
Externo à Instituição - TATJANA KEESEN DE SOUZA LIMA CLEMENTE - UFPB
Notícia cadastrada em: 01/11/2018 10:17
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