Banca de DEFESA: ROSILENE RODRIGUES SANTIAGO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : ROSILENE RODRIGUES SANTIAGO
DATA : 09/07/2018
HORA: 09:00
LOCAL: Sala de Reuniões do CONSEC
TÍTULO:

NANOSTRUCTURED LIPID CARRIERS CONTAINING AMPHOTERICIN B: DEVELOPMENT, IN VITRO RELEASE ASSAY, AND STORAGE STABILITY.

PALAVRAS-CHAVES:

Nanostructured lipid carriers, Amphotericin B, experimental design, in vitro release.

PÁGINAS: 32
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Nanostructured-lipid-carriers (NLC) can improve the encapsulation rate and the stability of drugs. The aim of this study was to develop an amphotericin B (AmB)-containing NLC (AmB-NLC). An experimental design was applied in order to determine the component concentration within the final formulation. The prepared NLC had their stability assessed on the basis of particle size, polydispersity index (PDI), zeta potential, and AmB recovery rate. NLC were also lyophilized (LYO) and optimized in order to improve their shelf-life. The experimental design presented the optimal component concentration as 7:3 (w/w) solid:liquid lipid ratio and 3% of surfactants. The produced NLC were white translucent, becoming yellow translucent when AmB was incorporated. For lyophilization, maltose was the best cryoprotectant using a 48 h freeze-drying cycle. Both the LYO-AmB-NLC and LYO-NLC were readily dispersible in water. The dried systems had slightly different physicochemical properties; however, they maintained their high encapsulation efficiency of above 90%. Additionally, DSC and XRD exhibited the crystallinity state of the particles. The in vitro release profile, assessed 24 h after particle preparation, fitted the Baker-Lonsdale model. In conclusion, all the results together revealed that the developed NLC can be an available alternative as a drug delivery system for AmB.

MEMBROS DA BANCA:
Interno - 346138 - ALDO DA CUNHA MEDEIROS
Interno - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Presidente - 1178187 - ERYVALDO SOCRATES TABOSA DO EGITO
Externo à Instituição - NEILA DE PAULA PEREIRA - UFBA
Externo à Instituição - TOSHIYUKI NAGASHIMA JUNIOR - UFCG