Banca de QUALIFICAÇÃO: DALIANA CALDAS PESSOA DA SILVA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : DALIANA CALDAS PESSOA DA SILVA
DATA : 03/11/2017
HORA: 09:00
LOCAL: PPGCSa
TÍTULO:

Up-expression of TCD8+ cells associated with oncogenic high-risk HPV in women with
low squamous intraepithelial lesions.


PALAVRAS-CHAVES:

Flow cytometry; Immunophenotyping; Human Papiloma virus


PÁGINAS: 30
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Objective: To compare the quantitative expression of T lymphocytes and subsets T-helper

(CD3+/CD4) and T-cytotoxic (CD3+/CD8+), B lymphocytes (CD19+) as well as NK cells
(CD16-56+) and NKT (CD3/CD16-56+) cells in HPV-infected woman’s, correlated with the
presence of low-risk and oncogenic HPV-DNA. Methods: Were analyzed 30 healthy women
and 30 patients with Low Squamous Intraepithelial Lesions undergoing HPV genotype
detection by hybrid capture. The presence of T lymphocytes (CD4 and CD8 subsets), CD19,
NK, and NKT cells were investigated by flow cytometry immunophenotyping. The average
number of cells in each group was verified using the Student t-test. A significance level of 5%
was adopted in all the tests carried out. The graph pad statistical program was used to
calculate the values. Results: We found a sharp increase in TCD8+ T lymphocytes among
patients with oncogenic HPV DNA and a statistically significant reduction in the expression of
NK and NKT cells in all groups of patients analyzed when compared with the healthy control
group. Furthermore, the quantitative evaluation of the CD19 was normal in patients exhibiting
LSIL and HPV when compared with the healthy control group. Conclusions: These
preliminary data suggest a correlation between the increased number of TCD8 lymphocytes
and oncogenic HPV DNA.


MEMBROS DA BANCA:
Presidente - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR
Externo ao Programa - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS
Externo ao Programa - 350753 - VALERIA SORAYA DE FARIAS SALES
Externo à Instituição - GABRIELA VASCONCELOS DE ANDRADE - NENHUMA
Notícia cadastrada em: 20/10/2017 07:56
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