Banca de QUALIFICAÇÃO: VIVIANE BRITO NOGUEIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : VIVIANE BRITO NOGUEIRA
DATA : 23/08/2017
HORA: 08:30
LOCAL: CB - Psicobiologia
TÍTULO:

Sex-biased gene expression in frontal cortex in common marmosets (Callithrix jacchus) and prospect correlated behaviors

PALAVRAS-CHAVES:

Transcriptomics, sexual dimorphism, synaptic plasticity, adaptive strategies, neuropsychiatric primate model, knowledgebase

PÁGINAS: 15
GRANDE ÁREA: Ciências da Saúde
ÁREA: Medicina
RESUMO:

The common marmoset (Callithrix jacchus), a small New World monkey,  has been widely used as a biological model in neuroscience not only in an attempt to elucidate brain dysfunction in neuropsychiatric disorders but also for deciphering neural circuits involved in human social behaviors. In this regard, the availability of gene expression data derived from next-generation sequencing (NGS) technologies represents an opportunity for deeper studies on the genetic and epigenetic architecture of this species. Gene expression and alternative splicing profiles across tissues were analyzed in marmosets. To provide the translational value of this species we focused in sex-biased gene expression from the frontal cortex of male and female in common marmosets and compared to humans (Homo sapiens). In this study we found that genes whose expression is male-biased are conserved between marmosets and humans and enriched with "house-keeping" functions. On the other hand, female-biased genes are more related to neural plasticity functions involved in remodeling of synaptic circuits, stress cascades and visual behavior. Based on knowledge about dimorphic social behavior of male and female common marmosets we discuss that these differences might be linked to particular neuronal circuitry underlying the expression of the adaptive strategies in each sex and related to survival and reproductive behavior traits. Additionally, we developed and made available a knowledgebase - the CajaDB –providing a friendly interface for genomic, expression and alternative splicing data of marmosets together with a series of functionalities that allow the exploration of these data. CajaDB is available at cajadb.neuro.ufrn.br.

MEMBROS DA BANCA:
Externo ao Programa - 1149552 - ARRILTON ARAUJO DE SOUZA
Presidente - 6346130 - MARIA BERNARDETE CORDEIRO DE SOUSA
Externo ao Programa - 1507794 - RODRIGO JULIANI SIQUEIRA DALMOLIN