Banca de QUALIFICAÇÃO: ANDREZA CONCEIÇÃO VÉRAS DE AGUIAR GUERRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : ANDREZA CONCEIÇÃO VÉRAS DE AGUIAR GUERRA
DATA : 20/04/2017
HORA: 09:00
LOCAL: Sala da Pós Graduação de Biologia Estrutural e Funcional (Departamento de Morfologia/CB/UFRN)
TÍTULO:

Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line


PALAVRAS-CHAVES:

Libidibia ferrea. Colorectal cancer. Apoptosis. Antioxidant.


PÁGINAS: 31
GRANDE ÁREA: Ciências da Saúde
ÁREA: Saúde Coletiva
RESUMO:

Colorectal cancer is noted for being one of the most frequent of tumors, with expressive morbidity and mortality rates. In new drug discovery, plant-derived products stand out as a source capable of yielding safe and high-efficiency compounds. Well known in Brazilian popular medicine, Libidibia ferrea (Mart. Ex Tul.) L.P. Queiroz var. ferrea, has been used to treat a wide spectrum of conditions and to prevent cancer. Using methodologies that involved flow cytometry, spectrophotometry and RT-qPCR assays, fractionated extracts of L. ferrea (EF20T, EF40T, EF60T and EF80T) were evaluated at 24 h and/or 48 h for: their ability to inhibit cell proliferation; induce apoptosis through Bcl-2, caspase-3 and Apaf-1; their antioxidant activity and effects on important targets related to cell proliferation (EGFR and AKT) in the HT-29 human colorectal lineage. The results revealed high antiproliferative potential as compared to the controls, induction of apoptosis through the intrinsic pathway, and probable tumor inhibition activity through mediation of important targets in tumorigenesis. In addition, L. ferrea revealed antioxidant, lipid peroxidation and chemoprotective effects in healthy cells. Thus, L. ferrea derivatives have important anticancer effects, and may be considered promising molecular candidates for both innovations and treatments in colorectal cancer.


MEMBROS DA BANCA:
Externo ao Programa - 1519121 - MANUELA DOS SANTOS CARVALHO SCHIAVON
Externo ao Programa - 2477216 - NAISANDRA BEZERRA DA SILVA FARIAS
Presidente - 2329140 - RAIMUNDO FERNANDES DE ARAUJO JUNIOR
Notícia cadastrada em: 28/03/2017 08:54
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