Banca de QUALIFICAÇÃO: JOSIVAN GOMES DE LIMA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : JOSIVAN GOMES DE LIMA
DATA : 17/10/2017
HORA: 09:00
LOCAL: PPGCSA
TÍTULO:

CLINICAL AND LABORATORY DATA OF A LARGE SERIES OF PATIENTS WITH CONGENITAL GENERALIZED LIPODYSTROPHY


PALAVRAS-CHAVES:

Lipodystrophy, Diabetes, Insulin resistance, Berardinelli-Seip


PÁGINAS: 7
GRANDE ÁREA: Ciências Biológicas
ÁREA: Bioquímica
RESUMO:

Background: Berardinelli-Seip congenital lipodystrophy (BSCL) was initially described by Berardinelli in Brazil in 1954 and 5 years later by Seip in Norway. It is an autosomal recessive disease that leads to a generalized deficit of body fat, evolving with diabetes and hypertriglyceridemia. The aim of this study was to describe the clinical and laboratory characteristics of a large series of patients with BSCL. Methods: This is a cross-sectional study of patients with BSCL. A total of 54 cases of BSCL were diagnosed, treated and followed for the past 17 years. We report clinical and laboratorial data of 44 of those patients. Results: There was a predominance of female patients (27 patients), and the mean age was 21.3 ± 13.7 years old. The majority of patients (30/44; 68.2 %) were diabetic, and almost half of them (14/30 patients, 46.7 %) were on insulin. The mean body mass index was 19.6 ± 3.3 and the mean body fat measured by dual-energy X-ray absorptiometry (DEXA)

was 5.4 ± 0.8 %. Acanthosis nigricans, acromegaloid facies, atrophic cheeks, prognathism, phlebomegaly, and muscle hypertrophy were the most common clinical features. Only two patients had triglyceridemia lower than 150 mg/dl without the use of lipid-lowering drugs. Hyperinsulinemia was present in the majority of patients, and leptin values were very low in all patients. Conclusions: We report one of the largest series of patients with BSCL treated at a single medical center. Earlier identification of the mutations and a better understanding of the pathophysiology can aid to better treatment and decrease complications, potentially improving life quality and expectancy.


MEMBROS DA BANCA:
Externo ao Programa - 2442045 - ANDRE GUSTAVO PIRES DE SOUSA
Externo ao Programa - 8347651 - MARIA DE FATIMA PAIVA BARACHO
Presidente - 350647 - SELMA MARIA BEZERRA JERONIMO
Notícia cadastrada em: 19/10/2016 07:30
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