Banca de QUALIFICAÇÃO: CRISTINA MARIA DE ARAUJO MEDEIROS SANTOS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : CRISTINA MARIA DE ARAUJO MEDEIROS SANTOS
DATE: 28/04/2025
TIME: 13:00
LOCAL: Videoconferência
TITLE:

IMPACTO DE UMA DIETA ANTI INFLAMATÓRIA NA MODULAÇÃO DE CITOCINAS E QUALIDADE DE VIDA EM MULHERES COM ENDOMETRIOSE EM USO DE DIENOGESTE

KEY WORDS:

Endometriosis; Dienogest; Anti-inflammatory diet; Cytokines;

PAGES: 95
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

 

The search for biomarkers that have predictive and prognostic value in the pathophysiology of endometriosis is one of the objectives in the field of immunobiology. It is known that immunoregulatory molecules and the expression of pro- and anti-inflammatory mediators are important in the pathophysiology of endometriosis. Given this context, this study aims to evaluate the role of an anti-inflammatory diet in the modulation of cytokines and quality of life in women with endometriosis using dienogest. In this study, 82 women in the endometriosis outpatient clinic of a tertiary university hospital were stratified. Blood samples were collected by venipuncture for quantification of pro-inflammatory cytokines by flow cytometry using the CBA inflammation kit (Human Inflammatory Cytokines Kit: IL-8, IL-1, IL-6, IL-10, TNF, IL-12p70 – Catalog 551811, Becton Dickinson Biosciences Pharmingen, BD, San Diego, CA, USA) at time 0 and after a 6-month follow-up using an anti-inflammatory diet. Furthermore, validated instruments such as EHP-30, SMILE C and GSRS were applied to assess quality of life.

These data were subsequently correlated with the sociodemographic, clinical and laboratory data of these patients. The evaluation of mechanisms related to the pathophysiology of endometriosis brings an innovative approach within the scientific universe and, in this way, will expand scientific knowledge on the discovery of biomarkers as a tool for diagnosis, prognosis and/or treatment of endometriosis.

COMMITTEE MEMBERS:
Externa ao Programa - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA - UFRNPresidente - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS
Externo à Instituição - JOSE MARIA SOARES JUNIOR - USP
Externo ao Programa - ***.779.074-** - KLEYTON SANTOS DE MEDEIROS - UFRN