Banca de DEFESA: JORGE LUIZ DANTAS DE MEDEIROS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JORGE LUIZ DANTAS DE MEDEIROS
DATE: 30/08/2021
TIME: 14:00
LOCAL: videoconferência
TITLE:

INCREASED CARDIOVASCULAR RESPONSE TO THE 6-MINUTE WALK TEST AND ITS ASSOCIATION WITH THE ANKLE-BRACHIAL INDEX IN CONGENITAL GENERALIZED LIPODYSTROPHY

KEY WORDS:

Lipodystrophy, Metabolism, Cardiovascular response, Anklebrachial index, Six-min walk test

PAGES: 38
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Background: Congenital Generalized Lipodystrophy (LGC) is a rare disease characterized by metabolic outcomes such as hypertriglyceridemia, hyperinsulinemia, hypoleptinemia, hypoadiponectinemia, and diabetes mellitus. Cardiovascular and respiratory disturbances have been previously observed. Conversely, there are no studies regarding the peripheral arterial disease (PAD) occurrence and the cardiovascular (CV) response to submaximal functional exercise. This study assessed the PAD occurrence and the CV response to submaximal exercise in LGC subjects. Methods: Twelve LGC individuals and 12 healthy subjects matched for age and gender were included. The PAD and the exercise capacity were measured using the ankle-brachial index (ABI) and the sixminute walk test (6MWT), respectively. The genetic diagnosis sociodemographic, and anthropometric data were obtained. Correlations among metabolic parameters, ABI, and 6MWT were also performed. Results: We found that most LGC subjects presented normal ABI value (1.0 ≤ ABI ≤ 1.4). Only 25% (n=3) had ABI≤0.9. At baseline, LGC subjects showed reduced predicted walked distance (6MWD) (p=0.009), and increased heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressures after the 6MWT compared to healthy subjects (p<0.05). LGC subjects did not present changes in ABI and blood pressure 12 months after metreleptin (MLP) replacement, but they walked a greater 6MWD in comparison to baseline (p=0.04). Further, the measurements of 6MWD and right ABI were positively correlated in LGC subjects (p=0.03). Right ABI negatively correlated with glucose, triglycerides, and VLDL-c (p<0.05). Conclusions: Our data suggest that LGC subjects had lower functional capacity and needed higher cardiac effort for similar performance of the 6MWT. There was also an association between ABI and 6MWD

BANKING MEMBERS:
Presidente - 1545315 - GUILHERME AUGUSTO DE FREITAS FREGONEZI
Externa à Instituição - JESSICA DANIELLE MEDEIROS DA FONSECA - SMS
Externa ao Programa - 1837354 - JULLIANE TAMARA ARAUJO DE MELO CAMPOS