Banca de DEFESA: VAGNER DEUEL DE OLIVEIRA TAVARES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : VAGNER DEUEL DE OLIVEIRA TAVARES
DATE: 12/07/2024
TIME: 13:30
LOCAL: Videoconferência
TITLE:

EXPLORING THE ADJUVANT EFFECT OF PHYSICAL EXERCISE IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER: A RANDOMIZED CLINICAL TRIAL

KEY WORDS:

Multimodal Exercise, Depression, Cardiorespiratory, Inflammation, Lifestyle.

PAGES: 108
BIG AREA: Ciências Humanas
AREA: Psicologia
SUBÁREA: Psicologia Fisiológica
SPECIALTY: Psicobiologia
SUMMARY:

Although antidepressants represent an advance in the treatment of Major Depressive Disorder (MDD), their efficacy is limited and accompanied by undesirable side effects. This has driven the investigation of complementary treatments, such as physical exercise. However, adherence to exercise is challenging despite its known benefits for physical and mental health. This study aimed to evaluate physical and mental health indicators concerning the severity of MDD pre-treatment and to validate a home-based exercise protocol guided by effort, pleasure, and affect towards exercise, to improve patient adherence and investigate the potential adjunctive role of physical exercise to pharmacotherapy, observing changes in physical and mental health parameters. A randomized, controlled, open clinical study was conducted with MDD patients, involving two experimental groups: pharmacotherapy only (control) and exercise combined with pharmacotherapy, as part of the Programa de Enfrentamento à Tristeza, which includes other adjunctive therapies such as yoga and meditation. Pre-treatment health indicators showed significant variations related to depression severity. Notably, the exercise group had a lower dropout rate than the control group, indicating good adherence to the emotion and effort-guided protocol. Additionally, physical exercise proved effective in improving cardiorespiratory fitness and was an important complement to pharmacological treatment, contributing to a greater reduction in depressive symptoms, side effects, and systemic inflammation levels. Furthermore, the anti-inflammatory response predicted a better clinical response to treatment, exclusively in the exercise group. Thus, the exercise protocol developed specifically for MDD patients was effectively validated, demonstrating high adherence and significantly contributing to the physical and mental improvement of the participants. It is also important to guide the exercise protocol by effort, pleasure, and affect, along with evaluating the patients' baseline profile considering MDD severity, to develop more personalized treatments and create protocols that maximize treatment benefits.

COMMITTEE MEMBERS:
Presidente - 1718518 - NICOLE LEITE GALVAO COELHO
Interna - 1350337 - FIVIA DE ARAUJO LOPES
Externo ao Programa - 2413545 - LEONIDAS DE OLIVEIRA NETO - UFRNExterna à Instituição - HELENA FERREIRA MOURA - UnB
Externo à Instituição - FELIPE BARRETO SCHUCH - UFSM