Banca de DEFESA: CARLA JÉSSICA RODRIGUES SALES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : CARLA JÉSSICA RODRIGUES SALES
DATA : 31/08/2018
HORA: 08:30
LOCAL: Sala de aula do PPG em Psicobiologia
TÍTULO:

Endocrine and behavioral profile of common marmoset (Callithrix jacchus) at young age in the family group and during social isolation

PALAVRAS-CHAVES:

ontogenetic development, stress, sex differences, cortisol, behavior, model of depression

PÁGINAS: 60
GRANDE ÁREA: Ciências Humanas
ÁREA: Psicologia
SUBÁREA: Psicologia Fisiológica
RESUMO:

Common marmoset, Callithrix jacchus, is a New World primate considered an important experimental model. Until very recently, most of the studies have been performed using adult marmosets in different areas of interest, such as genetics, metabolism and, mainly, neurosciences. The study of the stress response in this model has also produced relevant information, where mature males and females present a behavioral and endocrine dimorphic response. In the perspective of current models for depression and considering the high prevalence of 18% of this neuropsychiatric disorder in the human population, and around 14% in adolescents, the use of these animals during development is in the initial phase of research. Therefore, studies with immature animals are necessary to validate this experimental model in the early stages of its development. The objective of this study was to describe the hormonal and behavioral changes in immature males and females within family group and during social isolation. Twenty-nine animals with ages of 6 (n = 8, 4 males), 9 (n = 10, 5 males) and 12 (n = 11; 5 males) were used, where data collection occurred in the family group (baseline), in the first 2 days (FEI) and in the last two days (FEF) after separation for 3 weeks, and two days after the animal returned to the family group (reunion). Females presented significant changes in cortisol at 3 studied ages and males responded by increasing cortisol faster than females at 9 months, while cortisol elevation at this age in females occurred at the final stage of the separation period. The behavior of the females showed significant differences in the autogrooming in relation to that of males and the behavior of scent marking showed an increasing profile with the age of both males and females. The food intake behavior, modulated by the hypothalamic-pituitary-adrenal (HPA) axis, showed a decrease in the final phase of the study in females and needs to be investigated in males. These results indicate the potential of common marmosets, at young age, as an important experimental model, when exposed to isolation, for the study of psychiatric disorders in adolescence, and emphasizes that the protocols should be aware to the sex and age of the animals in their use as experimental models.

MEMBROS DA BANCA:
Interno - 1149552 - ARRILTON ARAUJO DE SOUZA
Presidente - 6346130 - MARIA BERNARDETE CORDEIRO DE SOUSA
Externo à Instituição - MARIA DE FATIMA PEDROSA PINTO BARBOSA - UnP