Banca de DEFESA: LUIZ RICARDO TEIXEIRA DE FARIAS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LUIZ RICARDO TEIXEIRA DE FARIAS
DATE: 29/07/2025
TIME: 15:00
LOCAL: Google Meet
TITLE:

SYSTEMATIC REVIEW OF THE POTENTIAL EFFECT OF Passiflora edulis ON DIABETES MELLITUS.

KEY WORDS:

Passifloraceae; passion fruit; Diabetes mellitus; antidiabetic.

PAGES: 61
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Diabetes mellitus (DM) is a chronic metabolic disorder of high global prevalence, characterized by hyperglycemia resulting from deficiency in insulin secretion or action, a condition that leads to progressive dysfunctions in target organs, such as the heart, kidneys, eyes, blood vessels and nervous system. Despite the efficacy of available pharmacological treatments, their adverse effects and therapeutic limitations have driven the search for safe and natural alternatives. In this context, the species Passiflora edulis, widely cultivated in Brazil and traditionally used for the sedative properties of its leaves, has aroused interest regarding the antidiabetic potential of its by-products, especially the peels and seeds, generally discarded in the food industry. This systematic review aimed to evaluate the available in vivo preclinical evidence on the effects of P. edulis in the management of DM. The search was conducted according to the PRISMA guidelines, in the PubMed, Embase and Web of Science databases, and the protocol was registered in the PROSPERO platform (CRD42023472406). Experimental studies with diabetic animal models treated with different preparations of P. edulis were included, and the risk of bias assessment was performed using the SYRCLE RoB tool. Of the 22 eligible studies, 18 reported significant reduction in glycemia, with reductions of up to 71% in glucose levels, both alone and as an adjuvant to insulin. Consistent effects on the modulation of the lipid profile and antioxidant activity were also observed. The barks were the most investigated part of the plant (11 studies), with emphasis on the aqueous extract, whose superiority is attributed to the higher content of bioactive compounds such as pectin, phenols and flavonoids. The proposed mechanisms of action include the reduction of intestinal glucose absorption, stimulation of insulin secretion, partial regeneration of pancreatic β-cells, and activation of relevant metabolic pathways such as PI3K/AKT and AMPK, in addition to antioxidant and hypolipidemic effects. However, important methodological limitations were identified, such as the lack of standardization in the doses used and the scarcity of phytochemical characterization of the extracts, factors that compromise the reproducibility of the findings. Nevertheless, the data suggest that P. edulis barks, due to their high functional value and availability as agro-industrial waste, represent a promising, sustainable and low-cost alternative in the adjuvant treatment of diabetes mellitus and its complications.

COMMITTEE MEMBERS:
Presidente - 1490222 - SILVANA MARIA ZUCOLOTTO LANGASSNER
Externo ao Programa - 2511670 - ALISSON MACARIO DE OLIVEIRA - UFRNExterno à Instituição - GEISON MODESTI COSTA