Banca de DEFESA: BEATRIZ MAIA DE PAIVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : BEATRIZ MAIA DE PAIVA
DATE: 03/06/2025
TIME: 09:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

STOX1 Gene and Preeclampsia Risk: A Systematic Review and Meta

Analysis

KEY WORDS:

Systematic review; Preeclampsia; STOX1.

PAGES: 92
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Preeclampsia (PE) is a multifactorial hypertensive disorder of pregnancy and a major

contributor to maternal and perinatal morbidity worldwide. While the pathogenesis of

PE is complex, involving abnormal placentation, endothelial dysfunction, and

inflammatory responses, growing evidence suggests a genetic component. The

STOX1 gene, particularly the Y153H and -922 T>C polymorphisms, has been

implicated in PE susceptibility, though findings remain inconsistent. This systematic

review and meta-analysis were conducted following PRISMA guidelines and

registered in PROSPERO (CRD42023465306). A comprehensive search across eight

databases included observational studies evaluating STOX1 gene polymorphisms in

pregnant women with PE versus normotensive controls. Data was extracted

independently by two reviewers. Pooled odds ratios (ORs) and 95% confidence

intervals (CIs) were calculated using fixed- or random-effects models, based on

heterogeneity assessed by the I² statistic. Study quality was evaluated using the

Newcastle-Ottawa Scale (NOS). Four studies were included, totaling 1,906 cases and

3,019 controls. Three studies examined the STOX1 Y153H variant, which showed no

statistically significant association with PE in any genetic model (dominant, recessive,

codominant, or allelic). Meta-analyses revealed high heterogeneity, particularly in the

allelic comparison (I² = 99.6%). One study on the -922 T>C promoter polymorphism

found a significant association with increased PE risk, especially in early-onset PE

(OR = 2.01, 95% CI [1.11–3.65], p = 0.02), though it was not included in the meta

analysis due to lack of comparators. This review found no consistent evidence linking

STOX1 Y153H to PE risk. However, the -922 T>C variant may contribute to

susceptibility in specific PE subtypes. Larger, multiethnic studies integrating genetic,

transcriptomic, and clinical data are needed to clarify the role of STOX1 in PE

pathogenesis.

COMMITTEE MEMBERS:
Externa à Instituição - AYANE CRISTINE ALVES SARMENTO - LNRCC
Interna - ***.474.624-** - KARLA SIMONE COSTA DE SOUZA - UFRN
Presidente - 1055045 - MARCELA ABBOTT GALVAO URURAHY