Banca de QUALIFICAÇÃO: GIOVANI JARDINI LAVIERI

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : GIOVANI JARDINI LAVIERI
DATE: 11/03/2025
TIME: 10:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

miRNAs as biomarkers in Lyme Disease: a review

KEY WORDS:

Lyme disease, miRNA, Biomarker, Borrelia burgdorferi, Lyme Arthritis, Lyme Carditis, Neuroborreliosis.

PAGES: 114
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Lyme disease, caused by bacteria of the Borrelia burgdorferi species and transmitted by ticks

of the Ixodes genus, is the most common tick-borne infection in the United States and Europe.

The disease manifests in three stages: early localized (erythema migrans), early disseminated

(flu-like symptoms, neurological and cardiac abnormalities), and late disseminated (arthritis

and neurological deficits). Early diagnosis is challenging, requiring further development of

diagnostic tests. miRNAs, small RNA molecules that regulate gene expression, are emerging

as potential biomarkers and therapeutic targets due to their stability and ability to reflect

pathological states, including bacterial infections such as Lyme disease. Studies indicate that

exosomal miRNAs play a crucial role in cellular communication and the regulation of

pathophysiological processes, highlighting their importance in inflammatory response and

immunity during infections and conditions associated with Lyme disease. This review aimed

to identify potential miRNA biomarkers in Lyme disease. The research was conducted in the

PubMed, Embase, ScienceDirect, Web of Science, and LILACS public databases using the

following search terms: "Lyme Disease" OR "Borrelia burgdorferi" OR "B. burgdorferi" OR

"Lyme Borreliosis" OR "Lyme Arthritis" OR "Lyme Carditis" AND "MicroRNA" OR "miRNA"

OR "miRNAs" OR "miR". miR-146a-5p plays a key role in the negative regulation of the

inflammatory response, indicating that this miRNA may be a relevant biomarker for monitoring

inflammation and pathological processes in the dermal manifestation of the disease and Lyme

arthritis. miR-155 plays a crucial role in regulating the inflammatory response in Lyme carditis,

while miR-145 and miR-146b are involved in microglial activation and inflammation, making

them promising biomarkers and therapeutic targets for Lyme disease.

COMMITTEE MEMBERS:
Interna - 1218940 - ANTONIA CLAUDIA JACOME DA CAMARA
Presidente - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Interna - ***.278.414-** - RAQUEL COSTA SILVA DANTAS KOMATSU - UFRN