Banca de QUALIFICAÇÃO: CLEANNE CESARIO LIMA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : CLEANNE CESARIO LIMA
DATE: 30/09/2024
TIME: 09:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/uyw-qsns-gpg
TITLE:

HYBRID SYSTEMS BASED ON POLOXAMINE AND LAPONITE AS NANOCARRIERS OF THE DRUG FLUCONAZOLE FOR VAGINAL APPLICATION IN THE TREATMENT OF CANDIDIASIS

KEY WORDS:

phase transition; pH; temperature; nanohybrid; fluconazole; Laponite; Tetronic.

PAGES: 91
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Tetronics® are micelle-forming copolymers capable of reversibly transitioning between sol-gel phases depending on concentration, pH, and temperature. They can be used in controlled drug delivery systems for poorly water-soluble drugs. Tetronic® T1304 was tested for the incorporation of fluconazole for vaginal application in the treatment of candidiasis. This polymer was chosen for its biological activity, particularly its use in treating fungal infections, and due to fluconazole's low aqueous solubility, which limits its bioavailability and systemic administration. To assist in the physicochemical stability of the micelles, the synthetic hectorite Laponite RD®, a rheological modifier that forms hydrogels, was added. Samples were prepared by varying the polymer concentration between 5 and 10% and the Laponite concentration between 1.5 and 3%. The parameters analyzed thus far include phase behavior studies, rheological behavior of the systems, and particle size through dynamic light scattering. The study aims to continue the analyses and further investigations through transmission electron microscopy, release kinetics profile, bioadhesion assays, and some microbiological tests.

COMMITTEE MEMBERS:
Presidente - 2276354 - LEANDRO DE SANTIS FERREIRA
Interno - 6330567 - TULIO FLAVIO ACCIOLY DE LIMA E MOURA
Externa ao Programa - 1754360 - WALDENICE DE ALENCAR MORAIS LIMA - null