Banca de DEFESA: RENATA KELLY DE FREITAS MANO
Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.STUDENT : RENATA KELLY DE FREITAS MANO
DATE: 29/08/2024
TIME: 09:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/bbj-neeq-fyj
TITLE:
KEY WORDS:
Pre-eclampsia. Vitamin D. Inflammatory markers. Angiogenic factors.
PAGES: 150
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Pre-eclampsia (PE) is a multifactorial and multisystemic disease whose diagnostic criteria are hypertension, after 20 weeks of gestation, accompanied by proteinuria and/or target organ dysfunction. PE is associated with several maternal and fetal complications, which can culminate in death. Thus, the identification of biomarkers with diagnostic power can lead to early interventions, minimizing complications. Some studies have evaluated the association of Vitamin D deficiency with the development and severity of PE. Furthermore, there is evidence that inflammatory markers and factors involved in angiogenesis can be used as PE biomarkers. Therefore, the objective of this study was to investigate whether there is an association between vitamin D deficiency and inflammatory and angiogenic markers in PE. For this, a systematic review was prepared in accordance with the PRISMA guidelines and registered in PROSPERO (CRD42021262723). PubMed; Lilacs; Scopus; Embase; Web of Science; Science Direct; Cochrane Library and Gray-literature: CAPES and Google Scholar were the databases used to search for articles published until July 2021, without language restrictions. The clinical question was prepared according to the PICOT strategy, with observational studies (cross-sectional, case-control and cohort) that assessed serum concentrations of inflammatory markers (IL-6, TNF-α, IL-4 and IL-10) being eligible. and angiogenic markers (PIGF, VEGF, sFlt-1 and endoglin), as well as serum vitamin D concentration, with the main outcome being the association of these markers with vitamin D deficiency. The stages of selection by title and abstract, full text reading and data extraction were carried out by two researchers independently and a third to decide conflicts. In total, 353 articles were retrieved by the search strategy and 3 articles met the inclusion criteria. The methodological quality of the studies was assessed using the Newcastle-Ottawa scale and all presented a low risk of bias. Vitamin D deficiency was found in all pregnant women with PE. In all studies, pregnant women in the PE group had lower plasma levels of vitamin D than pregnant women in the control group. It was also observed that vitamin D concentrations were lower in pregnant women with early-onset PE than in pregnant women with late-onset PE, as well as in pregnant women diagnosed with severe PE compared to pregnant women with mild PE. Therefore, vitamin D deficiency may be strongly correlated with the development and severity of PE.
COMMITTEE MEMBERS:
Externo à Instituição - JEFFERSON ROMÁRYO DUARTE DA LUZ - UEAP
Interna - ***.474.624-** - KARLA SIMONE COSTA DE SOUZA - UFRN
Presidente - 1055045 - MARCELA ABBOTT GALVAO URURAHY