Banca de DEFESA: MARIA IMACULADA CONCEIÇÃO FERREIRA DE CARVALHO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA IMACULADA CONCEIÇÃO FERREIRA DE CARVALHO
DATE: 23/08/2024
TIME: 15:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/kzt-wncp-dkv
TITLE:

Podocyte proteins as urinary biomarkers of glomerular injury in early stage: a systematic review


KEY WORDS:
Glomerular injury. Nephrin. Podocalyxin. Podocin. Synaptopodin. Urinary biomarkers.

PAGES: 132
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
The use of podocyte proteins as urinary biomarkers may be a promising
noninvasive tool for detecting early-stage glomerular injury. After podocyte injury,
the appearance of podocyte proteins in urine may identify glomerular injury before
the onset of albuminuria. Early detection may contribute to the adoption of timely
treatment, delaying or reducing disease progression. The objective was to
analyze the scientific evidence on the use of podocyte proteins as urinary
biomarkers of early-stage glomerular injury. A protocol was developed and
published in PROSPERO (CRD42021265630). A systematic review was
performed following the PRISMA (Preferred Reporting Items for Systematic
Reviews and Meta-Analyses) recommendations. The search was performed for
articles published until April 2024 in the PubMed, Embase, Web of Science,
Scopus and Google Scholar databases, without language restrictions. The
clinical question was formulated according to the PIRD strategy and
observational case-control studies were included according to the eligibility
criteria. The studies were selected independently by three authors who extracted
the data using a standardized form developed and validated by the authors. The
risk of bias was assessed using the Newcastle-Ottawa Scale (NOS). The R
CORE TEAM, 2020 software was used for quantitative synthesis. The search
strategy retrieved 3,476 studies, of which 20 were read in full and 8 were included
in the review. The Grading of Recommendations Assessment, Development and
Evaluation (GRADE) method was used. Two studies presented a low risk of bias
and the other six, a moderate risk. The certainty of evidence for early-stage
glomerular injury was considered low for podocin and very low for nephrin and
podocalyxin. In conclusion, the analyzed studies demonstrate the potential of
nephrin, podocin and podocalyxin proteins in the diagnosis of glomerular injury in
normoalbuminuric groups, allowing early-stage identification of the disease.

COMMITTEE MEMBERS:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externa à Instituição - ANA PAULA FERREIRA COSTA - LNRCC
Interna - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Notícia cadastrada em: 06/08/2024 11:30
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