Banca de DEFESA: PRISCILLA KARILLINE DO VALE BEZERRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : PRISCILLA KARILLINE DO VALE BEZERRA
DATE: 28/11/2022
TIME: 09:00
LOCAL: SALA 2 DO PPGCF
TITLE:
Drug-related problems in hypertension and gestational diabetes mellitus: a hospital cohort

KEY WORDS:
Drug therapy, High risk pregnancy, Gestational diabetes mellitus, Gestational hypertension, Clinical pharmacy service.

PAGES: 134
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Pregnant women are particularly vulnerable to medication-related problems (DRPs),
especially those at high risk. Despite their relevance, data on frequency, type, cause,
and associated factors in this population are scarce. In Latin America, as far as we
know, there are no studies on this topic. The aim of this study was to characterize the
PRMs in high-risk pregnant women with gestational hypertension (GH) and gestational
diabetes mellitus (GDM) according to frequency, type, cause, and factors associated
with their occurrence in the hospital setting. This was an observational, longitudinal,
prospective study that included 571 hospitalized pregnant women with GH and GDM
conditions using at least one medication. The PRMs were classified according to
Classification for Drug-Related Problems (PCNE V9.00). In addition to descriptive
statistics, a multivariate logistic regression model was used to determine the factors
associated with the PRMs. Preliminary results indicate a total of 873 identified DRPs.
The most frequent DRPs were related to therapeutic ineffectiveness (72.2%) and
occurrence of adverse events (27.0%), and the main pharmacological classes involved
were insulins and methyldopa. Then, the first five days of treatment, the ineffectiveness
of insulin (24.6%), associated with underdose (12.9%) or insufficient frequency of
administration (9.5%) and methyldopa associated with the occurrence of adverse
reactions (40.2%) in the first 48h, stand out. Lower maternal age (OR 0.966, 95% CI
0.938 - 0.995, p = 0.022), lower gestational age (OR 0.966, 95% CI 0.938 - 0.996, p =
0.026), report of drug hypersensitivity (OR 2.295, 95% CI 1.220 - 4.317, p = 0.010),
the longer treatment time (OR 1.237, 95% CI: 1.147 - 1.333, p = 0.001) and number of
prescribed medications (OR 1.211, 95% CI: 0.240 - 5.476, p = 0.001) were risk factors
for occurrence of DRPs. In summary, the DRPs are frequent in pregnant women with
GH and GDM, predominantly therapeutic ineffectiveness associated with insufficient
insulin dose and occurrence of adverse events, especially methyldopa adverse
reactions in the first 48h of treatment, with a tendency to decrease until the 5th day.

COMMITTEE MEMBERS:
Externa ao Programa - 347795 - IVONETE BATISTA DE ARAUJO - nullPresidente - 2432313 - RAND RANDALL MARTINS
Externa à Instituição - YONARA MONIQUE DA COSTA OLIVEIRA - UFCG
Notícia cadastrada em: 31/10/2022 17:35
SIGAA | Superintendência de Tecnologia da Informação - (84) 3342 2210 | Copyright © 2006-2024 - UFRN - sigaa07-producao.info.ufrn.br.sigaa07-producao