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The respective dissertation has as a question or objective to examine how the notion-method of poetic reason applies or relates to that of persona in the Zambranian work, in order to demonstrate that without the exercise of poetic reason, there is no realization of persona. Thus, the aim is to determine the foundation of the concepts of poetic reason and persona, as well as to highlight their relationship in the work of Maria Zambrano (historical-bibliographic research). Therefore, beyond the critical analysis of the historical, political and philosophical panorama (political crisis in Spain and Europe, and crisis of reason)which make it possible to identify the underlying concerns and motivations in his work - which are the origins of the respective notions investigated; is also considered, from the systematic reorganization of the writings and argumentation of Maria Zambrano, the stages and thematic axes of his thought, critical or negative and affirmative: in which an ethical and political dimension is presented, as well as metaphysical and epistemological, which leads at a time, contributions, both in the areas of knowledge cited, as to the philosophical aesthetics. That said, this path allows us to identify, understand and justify the origins, the relations and the ends of the respective notions.