Banca de QUALIFICAÇÃO: BYANCA RODRIGUES CARNEIRO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : BYANCA RODRIGUES CARNEIRO
DATE: 13/08/2025
TIME: 14:30
LOCAL: Sala de reuniões da GEP
TITLE:

Evaluation of vitamin E supplementation on the nutritional status of pregnant women

KEY WORDS:

Pregnancy; Alpha-tocopherol; Preeclampsia; Systematic Review; Clinical Trial

PAGES: 116
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Vitamin E plays an essential antioxidant role during pregnancy, helping protect against oxidative stress. Its deficiency is associated with an increased risk of preeclampsia (PE) and adverse outcomes for both mother and baby. Therefore, understanding the effectiveness of intervention measures that can mitigate vitamin E deficiency (VED) is crucial for managing adverse events during pregnancy. In this context, this study evaluated the impact of maternal vitamin E supplementation during pregnancy in two investigations: (1) to identify vitamin E supplementation during pregnancy and its effects on the nutritional status of the mother-child dyad, examined through a systematic review; and (2) to analyze the effects of daily supplementation with 400 IU of dl-alpha-tocopherol (α-TOH) on the α-TOH profile of pregnant women with severe preeclampsia, assessed in a randomized clinical trial (RCT). The review was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, with a protocol previously registered in PROSPERO (CRD42024529048). The search was performed in the PubMed/MEDLINE, Scopus, Web of Science, EMBASE, LILACS/SciELO, and Cochrane Library databases, including studies with human subjects that analyzed serum or tissue concentrations of vitamin E in pregnant women and/or their neonates. The randomized, double-blind, placebo-controlled clinical trial, currently ongoing, includes pregnant women diagnosed with severe preeclampsia. Participants were assigned to two groups: the intervention group, which receives 400 IU of α-TOH, and the control group, which receives inert excipients. The intervention lasts an average of 18 weeks. Socioeconomic, clinical, anthropometric, biochemical, and dietary intake data were collected, along with blood samples obtained before the start of supplementation (collection 1) and after delivery (collection 2). Serum concentrations of α-TOH were analyzed by Ultra-High Performance Liquid Chromatography, with vitamin E deficiency (VED) defined as values equal to or below 517 μg/dL. As results, of the six studies included in the systematic review, most evaluated combined supplementation of vitamins E and C, primarily in pregnant women with preeclampsia or gestational diabetes. Supplementation increased plasma levels of α-TOH in the pregnant women but did not show a significant impact on the levels observed in the newborns. Overall, the studies presented a low risk of bias and good methodological quality. In the preliminary results of the randomized clinical trial, 28 pregnant women were analyzed, all presenting vitamin E deficiency, with a mean serum α-TOH level of 251.1 (±103.1) μg/dL. Dietary intake was also inadequate, with an average of 5.9 mg/day. The results indicate that vitamin E supplementation may be a promising strategy to increase serum levels in pregnant women, especially in contexts of higher vulnerability. However, the data are still preliminary and do not support recommending its routine use. The decision regarding supplementation should be individualized, taking into account prior nutritional status monitoring and the pregnant woman’s risk profile.

COMMITTEE MEMBERS:
Presidente - 2578592 - KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES
Interna - 1837366 - DANIELLE SOARES BEZERRA
Externo à Instituição - KLEYTON SANTOS DE MEDEIROS - LNRCC