Banca de QUALIFICAÇÃO: CAROLINE FERNANDES DA COSTA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : CAROLINE FERNANDES DA COSTA
DATE: 30/04/2025
TIME: 09:00
LOCAL: DEPARTAMENTO DE ODONTOLOGIA-SALA DE AULA DO SETOR DA PATOLOGIA
TITLE:

IMMUNOHISTOCHEMICAL ANALYSIS OF IL-17, TNF-α, VEGF AND TGF-β IN NON-NEOPLASTIC PROLIFERATIVE LESIONS

KEY WORDS:

Pyogenic Granuloma; peripheral ossifying fibroma; peripheral giant cell lesion; histogenesis; clinical course.

PAGES: 67
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Non-neoplastic proliferative lesions (NNPLs) are a group of oral conditions characterized by excessive tissue proliferation of an inflammatory nature, resulting from an exaggerated soft tissue repair due to chronic injuries. They are most commonly observed on the gingival mucosa, with particular emphasis on pyogenic granuloma (PG), peripheral ossifying fibroma (POF), and peripheral giant cell lesion (PGCL). Although these lesions have an inflammatory nature and appear to be a response to local irritation or trauma, their etiopathogenesis remains poorly understood. Furthermore, research has been conducted to investigate a possible association among these pathologies, as they are distinct conditions but share etiological, clinical, and certain analogous histopathological characteristics. Therefore, it is essential to adopt strategies to better understand this relationship. In this context, this study aims to evaluate and compare the immunoexpression of IL-17, TNF-α, VEGF, and TGF-β in samples of PG, POF, and PGCL. Additionally, it seeks to correlate the expression of these markers with the clinicopathological characteristics of the analyzed NNPLs. This is a cross-sectional, observational, and retrospective study comprising 90 tissue specimens—30 PGs, 30 POFs, and 30 PGCLs—originating from the Laboratory of Pathological Anatomy and Cytopathology at the Department of Dentistry of UFRN. The study is characterized by the observation, analysis, and documentation of the clinical, demographic, and histopathological characteristics, as well as the immunohistochemical expression of the included tissue specimens. The results will be expressed quantitatively and semi-quantitatively, depending on the marker used. Subsequently, the data will be tabulated and subjected to appropriate statistical tests, adopting a significance level of 5% (p≤0.05). In this context, this research is expected to contribute to elucidating the mechanisms involved in the etiopathogenesis and biological behavior of NNPLs, thereby providing a foundation for future studies and helping to minimize the impact of recurrences through the establishment of more precise therapeutic management strategies.

COMMITTEE MEMBERS:
Interna - 2492713 - ERICKA JANINE DANTAS DA SILVEIRA
Presidente - 1258693 - LELIA MARIA GUEDES QUEIROZ
Interna - 1121806 - MARIA LUIZA DINIZ DE SOUSA LOPES