Banca de QUALIFICAÇÃO: LUANA BEATRIZ RIBEIRO LIMA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : LUANA BEATRIZ RIBEIRO LIMA
DATE: 09/04/2025
TIME: 08:30
LOCAL: Departamento de Odontologia - Sala de aula IV
TITLE:

IMMUNOEXPRESSION ANALYSIS OF SYNDECAN-1 AND BAX IN ORAL LICHEN PLANUS

KEY WORDS:

Oral Lichen Planus; Immunohistochemistry; Syndecan; Bax Protein.

PAGES: 44
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Oral lichen planus (OLP) is a chronic immune-mediated inflammatory disease that leads to the development of lesions in the oral mucosa. Although its pathogenesis remains uncertain, it is known that this condition is related to an immune response mediated by T lymphocytes against epithelial keratinocytes. Among the possible mechanisms of epithelial cell degeneration in OLP, apoptosis mediated by CD8+ T lymphocyte activation stands out, in which the Bax protein plays a well-established role in the literature. Additionally, alterations in the expression of proteins related to cell-cell and cell-matrix interactions may impact the integrity of the oral epithelium. Among these proteins, the Syndecan family, particularly Syndecan-1, is noteworthy. Thus, the objective of this study is to descriptively and comparatively analyze the immunohistochemical expression of Syndecan-1 and Bax proteins in reticular and erosive OLP. This research consists of a retrospective, cross-sectional, descriptive, semi-quantitative, and comparative study characterized by the analysis and documentation of the clinical characteristics of 40 previously diagnosed and archived cases of erosive and reticular OLP from the Laboratory of Pathological Anatomy and Cytopathology at UFRN. This will be followed by histopathological analysis and, finally, quantification of the mentioned proteins through immunohistochemical analysis. Subsequently, the results will be tabulated in Microsoft Excel® (Microsoft Corporation, USA) and subjected to appropriate statistical tests using SPSS for Windows (Statistical Package for Social Sciences; IBM, USA), with a significance level of 5% (p≤0.05). With this study, we aim to contribute to the understanding of the possible cellular mechanisms involved in the etiopathogenesis of OLP, as well as to provide a basis for both basic and clinical research related to the pathogenesis and treatment of this condition.

COMMITTEE MEMBERS:
Presidente - 1258707 - ANTONIO DE LISBOA LOPES COSTA
Interna - 1121806 - MARIA LUIZA DINIZ DE SOUSA LOPES
Interna - 350484 - ROSEANA DE ALMEIDA FREITAS