Banca de DEFESA: ANNA CLARA GOMES DE ARAÚJO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANNA CLARA GOMES DE ARAÚJO
DATE: 17/12/2024
TIME: 14:30
LOCAL: Departamento de Odontologia - Auditório
TITLE:

USE OF ANACARDIUM OCCIDENTALE LINN. EXTRACT IN THE TREATMENT OF ORAL LICHEN PLANUS: A RANDOMIZED CONTROLLED CLINICAL TRIAL

KEY WORDS:

Lichen Planus, Oral; Therapeutics; Phytotherapeutic Drugs; Anacardium.

PAGES: 116
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

INTRODUCTION: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous condition of unknown etiology and unpredictable clinical course, with no cure. It presents varied clinical manifestations in the oral mucosa, with erosive and atrophic forms, associated with pain, requiring symptomatic treatment. Topical corticosteroids are the first and main therapeutic option, despite the potential adverse effects associated with prolonged use. Thus, phytotherapeutics have been explored as promising alternatives for management of oral diseases, including OLP. OBJECTIVE: To analyze the efficacy of a phytotherapeutic gel based on the extract of Anacardium occidentale Linn. (cashew tree bark) in the treatment of symptomatic OLP lesions. METHODS: This study is a controlled, randomized, transversal, and single-blind clinical trial conducted with patients clinically and histopathologically diagnosed with symptomatic OLP. Participants were randomly assigned to two groups: experimental (n=), treated with a gel based on cashew bark extract, and control (n=), treated with 0.05% clobetasol propionate gel. Efficacy was evaluated weekly using a clinical score and the visual analog scale (VAS) for pain intensity. RESULTS: Both groups showed clinical improvement and pain reduction, with no statistically significant differences between treatments. The phytotherapeutic gel demonstrated comparable efficacy to corticosteroids, with fewer adverse events and an absence of oral candidiasis cases, observed in the control group. CONCLUSIONS: The A. occidentale L.-based phytotherapeutic gel proved to be a promising alternative to conventional treatment, offering additional benefits such as lower risk of adverse effects and economic accessibility. Future studies with larger sample sizes are recommended to consolidate these findings.

COMMITTEE MEMBERS:
Interna - 3218128 - AMANDA KATARINNY GOES GONZAGA
Presidente - 2492713 - ERICKA JANINE DANTAS DA SILVEIRA
Externa à Instituição - JAMILE MARINHO BEZERRA DE OLIVEIRA MOURA - UERN