Banca de QUALIFICAÇÃO: MIRELA MARTINA OLIVEIRA DE MOURA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MIRELA MARTINA OLIVEIRA DE MOURA
DATE: 18/12/2024
TIME: 11:00
LOCAL: Departamento de Odontologia - Sala de aula III
TITLE:

EFFECT OF MELATONIN USE ON ORTHODONTIC MOVEMENT IN RATS

KEY WORDS:

Orthodontics; Melatonin; Tooth Movement Techniques; Wistar Rats.

PAGES: 42
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Introduction: Orthodontic tooth movement (OTM) is a process of bone remodeling that can be influenced by external factors. Melatonin (MT) has been suggested to interfere with bone metabolism, potentially affecting this process. Objective: To investigate the effect of melatonin on orthodontic tooth movement in rats. Methods: This randomized in vivo experimental study will include 24 healthy male Wistar rats (Rattus norvegicus albinus), aged 8-12 weeks. The animals will undergo continuous orthodontic movement of the left upper first molars for 21 days and will be randomly divided into two groups: a Control Group (CG), receiving orthodontic movement and daily water intake (n=12), and a Melatonin Experimental Group (MEG), receiving orthodontic movement and daily melatonin administration (n=12). The extent of OTM will be assessed using micro-computed tomography (micro-CT). Morphological analysis will describe changes in the periodontal ligament, root resorption will be evaluated via tartrate-resistant acid phosphatase (TRAP) staining, and bone remodeling will be analyzed using immunohistochemical markers for osteoprotegerin (OPG) and RANK-L. Statistical analyses will be performed using SPSS version 20.0, with a significance level of p<0.05. Expected Results and Impact: This study seeks to elucidate the interaction between melatonin and orthodontic tooth movement to ensure that melatonin administration does not compromise orthodontic treatment efficacy.

COMMITTEE MEMBERS:
Presidente - 1958729 - RUTHINEIA DIOGENES ALVES UCHOA LINS
Interno - 1378325 - ARTHUR CESAR DE MEDEIROS ALVES
Interna - 350484 - ROSEANA DE ALMEIDA FREITAS