Banca de DEFESA: RAFAELA MEDEIROS DARC

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RAFAELA MEDEIROS DARC
DATE: 30/09/2024
TIME: 08:30
LOCAL: Departamento de Odontologia - Auditório
TITLE:

ANALYSIS OF IMMUNOEXPRESSION OF M1 AND M2 MACROPHAGES IN SQUAMOUS CELL CARCINOMAS OF THE LOWER LIP AND ORAL TONGUE

KEY WORDS:

Squamous cell carcinoma. Macrophages. Immunohistochemistry. Histopathological grading.

PAGES: 70
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUBÁREA: Clínica Odontológica
SUMMARY:

Squamous cell carcinoma is the most common malignant neoplasm in the mouth, accounting for more than 90% of cancers in this region. It is more common in the lower lip and oral tongue, which commonly show distinct biological behavior, tending to be less aggressive with a higher survival rate and lower risk of metastasis when it affects the lower lip, when compared to carcinomas in the oral tongue, which exhibit more aggressive progression and an unfavorable prognosis.Therefore, it is important to search for markers that can indicate these differences and, in this sense, some studies have analyzed the role of macrophages associated with tumors that can present different phenotypes, with the M1 phenotype being represented by immune effector cells capable of destroying neoplastic cells and the M2 phenotype having the ability to suppress the function of M1 macrophages, influencing angiogenesis and tissue repair. The objective of the present study was to evaluate the immunohistochemical expression of macrophage subpopulations in squamous cell carcinomas located in the oral tongue (OTSCC) and lower lip (LLSCC), investigating possible associations with histopathological characteristics.Twenty-four cases of OTSCC and 25 of LLSCC were selected. The morphological study classified them using the grading system proposed by the WHO (2005) and categorized them as poorly, moderately and well differentiated. The immunoexpression of antibodies was analyzed semiquantitatively. The study showed greater involvement in adult men for both locations. The morphological analysis indicated a predominance of the well differentiated grading for both locations. According to the immunohistochemical analysis, the immunopositivity scores for CD68 were significantly higher in the cases of LLSCC (p<0.005).The immunopositivity scores for CD68 and CD163 did not show statistically significant differences in relation to the histopathological grade of malignancy of SCC for both locations (p>0.05). The results of this study indicate no differences between macrophage subpopulations and the degree of histological differentiation of SCC; however, they indicate a better host response in LLSCC, with a predominance of the M1 subtype of macrophages, which may partly explain the less aggressive behavior in this location compared to the oral tongue.

COMMITTEE MEMBERS:
Interna - 350485 - HEBEL CAVALCANTI GALVAO
Externo à Instituição - MANUEL ANTONIO GORDON NUNEZ - UEPB
Presidente - 350484 - ROSEANA DE ALMEIDA FREITAS