PHARMACEUTICAL COMPOUNDS IN POTABLE WATER: SYSTEMATIC REVIEW AND METANALYSIS
pharmaceutical compounds; emerging micropollutants; supply water; metanalysis
Pharmaceutical compounds are commonly detected in the public supply water in concentrations that range between the ng/L to μg/L levels. Despite all the benefits, the increasing rate of pharmaceuticals consumption and a low water treatment efficiency for these compounds have aroused interest by researchers because of the potential effects on human health and the environment. Moreover, these compounds can cause changes in aquatic organisms’ structure and microbial community function. However, the regulatory framework for the control of the pharmaceutical compounds in the supply water is still incipient. Therefore, the analysis of these contaminants in water is fundamental. This study aims to investigate the occurrence of pharmaceutical compounds in treated water made available to the population through a systematic review of the subject in the scientific literature. For this purpose, we analyzed the articles published in journals between 2000 and 2021. The published information (drug concentration, city, method of detection of compounds) was statistically analyzed in MS Excel electronic spreadsheet. A database of 468 concentration values was composed of 143 drugs detected in 17 different countries in Europe, Asia, North America and South America. Approximately 83% of the concentrations were below 100 ng/L. The maximum concentrations of Prednisone (6,323 ng/L), Caffeine (5,845 ng/L), Betamethasone (2,620 ng/L), Iopamidol (2,400 ng/L), Triclocarban (2,055 ng/L) and Lincomycin (1,413 ng/L) were observed in Belo Horizonte, Campinas, Ganges River (India) and Ontario (Canada), respectively. The results revealed that the Caffeine, Iopamidol, Ibuprofen, Diclofenaco, Triclosan and Carbamazepine concentrations exceeded the Australian guidelines in 17x, 2,4x,1,4x, 4x, 2,1x and 2x, respectively. In addition, Carbamazepine was observed in approximately 70% of the countries evaluated. The results indicate that, despite representing a low potential risk to human health, the effects caused by the population's long exposure to these compounds need to be better evaluated.