Banca de DEFESA: KAHULA CAMARA DA COSTA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : KAHULA CAMARA DA COSTA
DATE: 26/06/2025
TIME: 09:00
LOCAL: https://meet.google.com/iag-tgex-aoh
TITLE:

ASSOCIATION BETWEEN CHRONOBIOLOGICAL, CLINICAL, AND SOCIODEMOGRAPHIC FACTORS AND GLUCOSE CONTROL IN INDIVIDUAL WITH TYPE 2 DIABETES MELLITUS

 

KEY WORDS:

chrononutrition, sleep, glycated hemoglobin, chronotype, gastrointestinal disorders

PAGES: 68
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

INTRODUCTION: Type 2 diabetes mellitus (T2DM) represents a major public health challenge, especially due to chronic complications arising from inadequate glycemic control. Evidence suggests that clinical factors (obesity, time since diagnosis, insulin use, and gastrointestinal symptoms) and sociodemographic characteristics (sex, race/skin color, socioeconomic status, and access to healthcare services) may influence glycemic regulation in individuals with T2DM. Additionally, sleep-wake irregularity patterns and inadequate chrononutritional behaviors—such as skipping breakfast and eating late at night—have been associated with worse glycemic indicators in the general population, highlighting the importance of investigating these factors in the management of T2DM, particularly in the Brazilian context. OBJECTIVE: To evaluate the association between chronobiological, clinical, and sociodemographic factors and glycemic control in individuals with T2DM in the municipality of Santa Cruz, RN. METHODS: This was a cross-sectional and observational study conducted with individuals aged over 18 years diagnosed with T2DM. Participants underwent anthropometric assessments (weight, height, and waist circumference) and completed five questionnaires: (1) Socioeconomic and Health Parameters Questionnaire; (2) International Physical Activity Questionnaire – short version; (3) Gastrointestinal Symptom Rating Scale; (4) Chrononutritional Profile Questionnaire; and (5) Munich Chronotype Questionnaire. Glycemic control was assessed by glycated hemoglobin (HbA1c), classified according to therapeutic targets established by the Brazilian Diabetes Society. The Mann–Whitney test was used to compare medians between adequate and inadequate glycemic control groups and between categories of dichotomous variables. A 5% significance level was adopted. RESULTS: A total of 85 individuals were assessed, mostly women (78.8%), with a median age of 59 years, low educational attainment (91.8% without higher education), and per capita income below the minimum wage (63.5%). Overweight was prevalent (69.0%), and 91.2% presented increased or greatly increased cardiometabolic risk. Chrononutritional behaviors showed a low prevalence of eating jetlag ≥1h (7.1%) and breakfast skipping (5.9%), while 90,6% reported lunchtime as the largest meal e 96.5% had eating windows ≥10h. The median sleep duration was 7.5 hours, without social jetlag and the corrected midpoint of sleep on free days (MSFsc) was 2:00 a.m., all without significant associations with glycemic control. Inadequate glycemic control was identified in 60.0% of the sample and was associated with male sex (p=0.031), insulin use (p=0.001), and nighttime eating (p=0.037). Associations were also observed with gastrointestinal symptoms (p=0.014), particularly reflux (p=0.022) and diarrhea (p=0.041). CONCLUSION: The study identified a high prevalence of inadequate glycemic control, which was associated with male sex, insulin use, nighttime eating, and higher gastrointestinal symptom scores. These findings reinforce the importance of multidimensional approaches in T2DM management and point to the need for future investigations into the impact of chronobiological behaviors on glycemic control.

COMMITTEE MEMBERS:
Presidente - 1110960 - JANE CARLA DE SOUZA
Interna - 1692571 - ANNA CECILIA QUEIROZ DE MEDEIROS
Externa à Instituição - RÍSIA CRISTINA EGITO DE MENEZES - UFAL