Banca de QUALIFICAÇÃO: FÁBIO HENRIQUE FERREIRA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : FÁBIO HENRIQUE FERREIRA SILVA
DATE: 21/02/2025
TIME: 09:00
LOCAL: Google Meet, meet.google.com/vkm-qzds-vpj
TITLE:

Analysis of protein-protein interaction networks in specific tissue

KEY WORDS:

Protein, interactions, genes, network

PAGES: 1
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Protein-protein interaction (PPI) networks are involved in supporting cellular life, forming metabolic pathways, protein complexes, and cellular structures. Canonical interaction networks provide an overview of potential interactions between proteins, regardless of the tissues in which they are expressed. Protein expression is not uniform across all tissues; some tissues share the same proteins, while others do not express them at all. A localized view of these networks by tissue offers a better resolution of these interactions, forming tissue-specific sub-networks composed only of proteins expressed within them. Analyzing these tissue-specific sub-networks reduces or eliminates the occurrence of false positives and improves the accuracy of results. In this work, we identify tissue-specific sub-networks across 52 tissues using gene expression data from the GTEx (The Genotype-Tissue Expression) project and compare them with the human interactome obtained from the STRING database.

COMMITTEE MEMBERS:
Interno - 2276280 - CESAR RENNO COSTA
Interno - 1507794 - RODRIGO JULIANI SIQUEIRA DALMOLIN