Banca de DEFESA: VITÓRIA NATÁLIA FERREIRA DE SENA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : VITÓRIA NATÁLIA FERREIRA DE SENA
DATE: 05/09/2025
TIME: 14:30
LOCAL: Departamento de Morfologia- CB
TITLE:

ACTION OF THE HYDROALCOHOLIC EXTRACT OF SPONDIAS TUBEROSA ARRUDA IN STREPTOZOTOCIN-INDUCED DIABETIC NEPHROPATHY IN RATS

KEY WORDS:

Diabetes Mellitus, Nephropathy, Spondylosis tuberosa, Morphology.

PAGES: 66
BIG AREA: Ciências Biológicas
AREA: Morfologia
SUBÁREA: Histologia
SUMMARY:

Diabetic nephropathy (DN) is the second leading complication of Diabetes Mellitus and one of the most concerning for global public health. Currently, pharmacological therapy for DM and nephropathy is severely limited due to the high number of side effects and ineffectiveness against its complications. Therefore, alternative treatments based on medicinal plants are potentially useful as an alternative and complementary treatment for this disease. The species Spondias tuberosa Arruda, popularly known as umbuzeiro, has been widely used in traditional medicine for the treatment of DM, but has been little explored scientifically. Therefore, the objective of this study is to evaluate the antidiabetic effect of the hydroalcoholic extract of Spondias tuberosa Arruda (ExSt) on DN based on biochemical, morphological, stereological, and molecular analyses in diabetic rats treated with this species. Forty-four Wistar rats were used, and DM was induced by streptozotocin (40 mg/kg i.p.). The groups were divided into: CT: non-diabetic animals; DM: animals with experimental DM; EX: non-diabetic animals treated with ExSt; DMEX: animals with experimental DM treated with ExSt; and DMIN: animals with experimental DM treated with insulin. ExSt (500 mg/kg, po) was administered daily for 30 days after the onset of DM, as was insulin. Blood and kidney samples were collected for analysis. Among the results observed, ExSt was unable to significantly reverse clinical and biochemical parameters; however, it demonstrated improvement in the established DN, since histopathological findings, cortical volume, glomerular volume, mean glomerular volume, glomerular basement membrane thickening, fibrosis, and markers of oxidative stress and tissue damage were minimized. Although further research is needed to more fully validate the action of ExSt in experimental DN, this work will contribute to a better understanding of the pathophysiology of DM and encourage the search for new forms of treatment using natural compounds available in the rich and diverse flora of Brazil.

COMMITTEE MEMBERS:
Presidente - 1714418 - KARINA CARLA DE PAULA MEDEIROS
Interna - 3357609 - FABIANE FERREIRA MARTINS
Interno - 2859541 - PEDRO PAULO DE ANDRADE SANTOS
Externa à Instituição - GICIANE CARVALHO OLIVEIRA - UFPB